Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2006-01-31
2006-01-31
Saidha, Tekchand (Department: 1652)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C435S229000, C435S252300, C435S320100, C536S023200
Reexamination Certificate
active
06991788
ABSTRACT:
Described herein are methods for producing recombinant forms of asparaginase derived fromWolinella succinogenes.In addition, methods for covalent modification of proteins, including asparaginases, by acylation are also provided. Certain embodiments provide for epitopic-labeling of the amino terminus ofW. succinogenesasparaginase. Additional embodiments concern methods for the therapeutic utilization of the native, homotetrameric form ofW. succinogenesasparaginase, as well as the use of epitopically-labeled or non-epitopically-labeled recombinantW. succinogenesasparaginase (or a covalently modified analog thereof) in the therapeutic treatment of malignant and non-malignant hematological disease and other diseases where asparagine depletion or deprivation would be efficacious or which respond to asparagine depletion or deprivation, as well as their potential utilization in the therapeutic treatment of autoimmune diseases such as rheumatoid arthritis, AIDS, and SLE.
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Eur. J. B
Children's Hospital Los Angeles
Perkins Coie LLP
Saidha Tekchand
LandOfFree
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