Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Reexamination Certificate
1997-04-23
2001-03-06
Tate, Christopher (Department: 1651)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
C424S059000, C424S123000
Reexamination Certificate
active
06197303
ABSTRACT:
The present invention relates to the use of natural algae extracts for the preparation of a product meant to prevent and to treat skin diseases, such as skin rashes or allergic reactions to cosmetic compositions. The invention also relates to natural algae extracts meant to prevent and to treat skin diseases.
BACKGROUND
The work of Susuma Tonegawa, Nobel Prize for Medicine in 1987, has shown the immunological function of certain cells of the epidermis, the Langerhans cells, with respect to localized aggressions in the epidermal layer of the skin. The Langerhans cells, that belong to a so-called lymphoid dendritic cell family, essentially are located in the middle layers of the epidermis. Despite their low density, their function is one of information and surveillance over the entire epidermis thanks, especially, to their dendritic nature and to their migratory capability.
The Langerhans cells are capable both of ingesting foreign bodies or allergens that have penetrated into the epidermis, and of transmitting antigens to special immuno-competent cells, the so-called T cells. The activation and protection produced by the Langerhans cells thus make it possible to stimulate the process of intrinsic defense of the epidermis.
Now, it is well known that these cells are directly exposed to ultraviolet rays resulting from exposure to the sun. Recent studies have shown that these radiations to a more or less important extent cause, on the one part, a decrease of the membrane markers, that is to say an alteration of the capability of the presentation of antigens to the immunocompetent cells and, on the other part, a disappearance of the dendrites that characterize the Langerhans cells. In case of extended exposure to the sun, the ultraviolet rays inhibit the Langerhans cells and the latter see their number decrease.
It has been sought to prepare products capable of protecting and of activating the Langerhans cells as a precaution against ultraviolet rays that frequently act on the epidermis.
Thus there are known products prepared from yeast membrane extracts, constituted by polysaccharides of vegetable origin. The products obtained, that are members of the &bgr;-1,3 glucanes family, are recognized by the membrane receptors of the Langerhans cells, and it enables these cells to maintain to some extent their macrophagic activity and to protect the immunocompetent cells of the epidermis.
A major drawback of the aforementioned products is found in the relatively high cost associated with their preparation process.
BRIEF DESCRIPTION OF INVENTION
The purpose of the present invention is to propose the use of natural extracts of algae for the preparation of a product meant to prevent and to treat skin diseases, as well as natural algae extracts meant to prevent and to treat these diseases, that are such that said product is obtained by a process relatively simple in execution, that is to say at a moderate cost.
To that end, the use, according to the present invention of natural algae extract for the preparation of the above-mentioned product is characterized in that it consists in using concentrated extracts of algae from the genus Chlorella.
According to another characteristic of the invention, said use of natural extracts of algae is characterized in that these extracts are meant to protect the Langerhans cells of the epidermis from ultraviolet radiations, and to stimulate the development of these cells following the above-mentioned radiations.
According to another characteristic of the invention, these natural algae extracts meant to prevent and to treat skin diseases are such that said algae are from the genus Chlorella.
The above-mentioned characteristics of the invention, as well as others, will appear more clearly upon reading of the following description of one example of execution, this description being given in relation to the attached drawing.
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Gedouin Jean
Vallee Romuald
Codif International S.A.
Laff, Whitesel & Saret, Ltd.
Tate Christopher
Whitesel J. Warren
LandOfFree
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