Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1984-07-13
1986-10-28
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
514251, 514825, 514904, 514905, A61K 31525, A61K 3342
Patent
active
046198296
DESCRIPTION:
BRIEF SUMMARY
The present invention refers to a new utilization of a single or a combination of various vitamins in the long-term therapy and/or prophylaxis of rheumatic diseases and a method for a long-term therapy and/or prophylaxis of rheumatic diseases.
Rheumatic diseases are widespread illnesses. In the USA alone about 30 million people suffer from arthritis, vide TIME MAGAZINE nr. 33, page 41, of Aug. 16, 1982. In the "Bulletin on the Rheumatic Diseases", vol. 32, nr. 1 (1982), page 1, published by the Arthritis Foundation, 3400 Peachtree Road, N.E. Atlanta, Ga. 30326, well-known therapies of rheumatoid arthritis are described.
The active substances collectively denominated vitamins are known, vide for example "Chemie Lexikon" by Prof. Dr. Hermann Rompp, Franckh'sche Verlagshandlung, Stuttgart.
It is described in the literature that neither short-term administration of vitamins nor high-level doses and/or so-called massive doses result in improvement in cases of rheumatoid arthritis; vide "Arthritis and Allied Conditions. A Textbook of Rheumatology". Editor: Joseph Lee Hollander, M.D., Seventh Edition. Published (in Europe) by Henry Kimpton, London, 1966, especially chapter 37, "Diet and Vitamins in Rheumatoid Arthritis", by Ronald Lamont-Havers, M.D.
Completely surprisingly, it now was found that rheumatic diseases can very successfully be treated by administration of at least one vitamin over a long period of time, be it prophylactically, for improvement and/or recovering.
The present invention refers to a new application of a single or a combination of various vitamins in the long-term therapy and/or prophylaxis of rheumatic diseases, especially such of inflammatory and degenerative nature, which involve joints, muscles, tendines and other parts of the locomotive system. Examples of such diseases are the inflammations of joints, chronical polyarthritis, a primary chronical polyarthritis and a general arthritis, especially a chronical and/or acute arthritis. The word "Polyarthritis" has hereafter to be interpreted as a collective expression for all possible forms of appearances of this disease(s) and its aetiology(ies), be it rheumatoid arthritis, primary chronical polyarthritis, osteoarthritis or any of the more than 100 other forms and variations, symptoms and syndromes of this disease. Hereafter the supreme and collective expression polyarthritis will be used.
The long-term therapy can be applied in any way; the systemic, injection and the topical administrations are preferred. Above all, however, the most preferable is the oral administration. The active substances acting as antirheumatic agents are administered orally and/or by injection in a dosage of about 0.25-2 mg/kg body weight per day, preferably 0.5-1 mg/kg/per day, although higher or lower doses can be applied too and easily determined by an expert, for example a physician. In vitamin combinations, the quantities of the specific vitamins can be varied. The dose can be administered as a single-dose or be dispensed over several part-doses. For the preferred oral administration the customary modes are to be taken into consideration, such as capsules, lacquered tablets or tablets. The manufacture of such modes of administration can be the customary one.
It is of the utmost importance that an application in conformity with the invention is a long-term therapy, in conformity with the invention. The expression "long-term therapy" ordinarily depends on the degree of the disease to be treated, the general state of health of the patient, his body weight and his age. The expert will easily find out how long the treatment has to last until improvement or complete healing is achieved. If need be, the daily administration of the active substance or of the combination of active substances can be interrupted for a specific period of time, for instance 1 week or 1 month or longer and can subsequently be resumed at the same, an increased or a decreased rate. Depending on the specificity of the patient's individuality, it has been found, priority has to be given to a
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