Utilities of olefin derivatives

Details Utilities of olefin derivatives Utilities of olefin derivatives

2008-09-09

2011-11-08

Weddington, Kevin E (Department: 1629)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

08053445

ABSTRACT:
Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I):in which Ar1and Ar2are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N═CZ2—, —CY2═CZ2—, —CY2Y3—CHZ2—, —S—, —O—, or the like; Y1, Y2, Y3, Z1and Z2are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1and Z2may be independently a linker group that may combine with Ar2and Ar1to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate thereof; are disclosed.

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