Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-10-30
2007-10-30
Graser, Jennifer E. (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S024300
Reexamination Certificate
active
10872768
ABSTRACT:
The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (ie. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study ofM catarrhalisare disclosed.
REFERENCES:
patent: WO93/03761 (1993-03-01), None
Aebi et al., “A protective epitope ofMoraxella catarrhalisis encoded by two different genes,”Infection and Immunity, 65:4367-4377, 1997.
Chen et al., “Evaluation of purified UspA fromMoraxella catarrhalisas vaccine in a murine model after active immunization,”Infection and Immunity, 64:1900-1905, 1996.
Chi et al., “Antibody response to P-protein in patients withMoraxella catarrhalisinfections,”Amer. J. Med., 88(Supp5A):25s-27s, 1990.
Eliasson, “a protein antigen characteristic ofMoraxella catarrhalis: serological identification of the genus,”Acta Path. Microbiol. Scand., 88:281-286, 1980.
Helminen et al., “A large antigenically conserved protein on the surface ofMoraxella catarrhalisis a target for protective antibodies,”J. of Infectious Diseases, 170:867-872, 1994.
Klingman and Murphy, “Purification and characterization of a high-molecular-weight outer membrane protein ofMoraxella(Branhamella)catarrhali,” Infection and Immunity, 62:1150-1155, 1994.
Aebi Christoph
Cope Leslie D.
Fiske Michael J.
Fredenburg Ross A.
Hansen Eric J.
Board of Regents , The University of Texas System
Fulbright & Jaworski
Graser Jennifer E.
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