USPA benzolyguanidines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546231, 546149, 546164, 546172, 546193, 5483001, 548491, 548563, 5483137, 564 85, 564237, 514183, 514212, 5142378, 514255, 514275, 514307, 514311, 514316, 514400, 514415, 514427, 514603, 514604, 540483, 540610, 544158, 544159, 544332, 544393, A61K 31445, C07D21128, C07C27910

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active

052927555

ABSTRACT:
Benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is equal to R(6)--S(O).sub.n -- or R(7)R(8)N--O.sub.2 S--

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Tammiso et al "Sedative 3,4,5-Trimethoxybenzoyl-N,N'-Diethyl guanidine in Animals" CA 81: 58245x (1974).
Schmid et al "Sodium/H Ion Exchange in Poreine Cerebral Capillary Endothelial Cells" CA 47(1)4775p (1992).
Resmick, B. M. "Fungicidal use of 1-(Alkoxyaroyl)-Guanidines" CA 94(25)203827 (1981).
Matsumoto et al "Effect of Guanidino Compounds on Choline Acetyltrausyerase and Actzlcholinesterase of Rabbit Brain" CA 89: 70774s (1978).
Duff, et al., "Amiloride. Antiarrhythmic and Electrophysiologic Actions in Patients with Inducible Sustained Ventricular Tachycardia," Circulation, vol. 79, No. 6, pp. 1257-1263, published Jun. 1989.
Buschauer, "Synthesis and in Vitro Pharmacology of Arpromidine and Related Phenyl(pyridylalkyl)guanidines, a Potential New Class of Positive Inotropic Drugs," Journal of Medicinal Chemistry, No. 8, pp. 1963-1970, Aug. 1989.

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