Using NMDA receptor antagonists to reduce damage due to laser tr

Details Using NMDA receptor antagonists to reduce damage due to laser tr Using NMDA receptor antagonists to reduce damage due to laser tr

1989-11-30

1991-05-07

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

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Taste or smell or chemical irritation to the eye, nose, or...

514289, 514922, A61K 4900, A61K 3144

Patent

active

050135406

ABSTRACT:
A method is disclosed for preventing the spread of damage in neuronal tissue that has been selectively burned by surgical laser treatment. Administration of an NMDA receptor blocker, such as dextrorphan, in conjunction with the laser treatment permits the site of the laser burn to be confined more precisely to the desired area, and prevents the spread of damage to surrounding tissue that would normally occur in the days after the laser treatment.

REFERENCES:
patent: 4806543 (1989-02-01), Choi
Tortella, Tips 10:501-507 (Dec. 1989).
Goldberg, Neuroscience letters 80:11-15 (1987).
Monyer, Brian Research 446:144-148 (1988).
Choi, Journal of Pharmacology and Experimental Therapeutics 242(2):713-720 (1987).
Leavens, Cancer Bulletin 41:237-240 (1989).
Jacques, Cancer Bulletin 41:211-218 (1989).
Thomsen, Cancer Bulletin 41:203-210 (1989).
Von Eschenbach, Cancer Bulletin 41:201-202 (1989).
Choi, Brain Research 403:333-336 (1987).
Kleinermanns, K. et al. "Laser Chemistry--What is its Current Status?" Angew. Chem. Int. Ed. Engl. 26:38-58 (1987).

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