Using amines or amino acids as mobile phase modifiers in...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

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10526301

ABSTRACT:
This invention relates to the use of amine, amino acid and amino acid ester mobile modifiers in normal phase chromatography to improve the resolution and or productivity of peptide and lipopeptide purification. This chromatographic method can be sued for either analytical or preparative scale purification.

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patent: 6130353 (2000-10-01), Bopp
patent: 6153590 (2000-11-01), Andersen et al.
patent: 11023558 (1999-01-01), None
D.J. Roush et al., “Preparative High-Performance Liquid Chromatography of Echinocandins”1998, vol. 827, pp. 373-389, J. of Chromatography A.

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