Using allosteric hemoglobin modifiers to decrease oxygen affinit

Details Using allosteric hemoglobin modifiers to decrease oxygen affinit Using allosteric hemoglobin modifiers to decrease oxygen affinit

1992-05-18

1993-09-28

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548473, 560 30, 560 31, 560 32, 568452, 568455, C09B 500, C07D20948

Patent

active

052487857

ABSTRACT:
A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.

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Lalezari et al., "LR16, A Compound with Potent Effects on the Oxygen Affinity of Hemoglobin, on Blood Cholesterol, and on Low Density Lipoprotein", Proc. Natl. Acad. Sci., USA 85 (1988), pp. 6117-6121.

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