Using a laser for cutting a hole in a capsule for controlled...

Details Using a laser for cutting a hole in a capsule for controlled... Using a laser for cutting a hole in a capsule for controlled...

2006-05-02

2006-05-02

Tran, Susan (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

C424S451000

Reexamination Certificate

active

07037521

ABSTRACT:
A method of fabricating capsules for sustained and controlled drug delivery. An array of capsules of a hydrophobic polymer is subjected to an extraction process to remove low-molecular-weight monomers, oligomers and polymers, and a laser is used to open accurately sized, spaced, and shaped holes in the capsules. In the process, the laser cutting oxidizes the hydrophobic polymer, making it sufficiently hydrophilic to allow wetting by the contents of the capsules. The capsules are then filled with a hydrophilic polymer covering the laser-cut opening and with one or more drugs for delivery, sealed, and removed from the array for mounting on suture tabs or other mounts. The use of the laser helps insure accurate and reliable delivery of drugs from the capsule.

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