Uses of THANK, a TNF homologue that activates apoptosis

Details Uses of THANK, a TNF homologue that activates apoptosis Uses of THANK, a TNF homologue that activates apoptosis

2007-07-10

2007-07-10

Harris, Alana M. (Department: 1643)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S004000, C435S007210, C435S007230, C436S057000, C436S086000, C436S087000, C530S300000, C530S350000, C530S387900, C530S388100, C530S388230, C530S388240, C530S389100, C530S391300

Reexamination Certificate

active

10170812

ABSTRACT:
The present invention is directed to the applications of a novel cytokine, named THANK, for TNF homologue that activates apoptosis, NF-κB and c-jun N-terminal kinase. Such applications include using THANK inhibitors to inhibit the activation of NF-κB and to treat a pathological condition caused by the activation of NF-κB. Also provided is a method of inhibiting growth of a wide variety of tumor cells by administering THANK protein.

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GenCore Database Sheets. Amino Acid Sequence Alignments Between Applicant'SEQ ID No. 1 and Patent's a Patent Application's Sequence 2.
GenCore database alignment between Applicant'SEQ ID No. 1 and U.S. Patent 6,689,579 B1 (filed Jan. 12, 1998).
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