Uses of tetrahydrobiopterin and derivatives thereof

Details Uses of tetrahydrobiopterin and derivatives thereof Uses of tetrahydrobiopterin and derivatives thereof

2011-01-04

2011-01-04

Spivack, Phyllis G. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07863275

ABSTRACT:
The present invention discloses methods of treating diabetic gastroparesis by administering tetrahydrobiopterin or a derivative thereof.

REFERENCES:
patent: WO 2005/020902 (2005-10-01), None
Gumaste et al., Digestion, (2008) 78(4): 173-9 (Abstract).
Shinozaki, K. et al. Abnormal Biopterin Metabolism is a Major Cause of Impaired Endothelium-Dependent Relaxaton Through Nitric Oxide/O2—Imbalance in Insulin-Resistant Rat Aorta:Diabetes, 1999, vol. 48, pp. 2437-2445.
Kawano, N. et al. Identification and Localization of Estrogen Receptor α- and β-positive Cells in Adult Male and Female Mouse intestine at Varous Estrogen Levels:Histochem Cell Biol, 2004, vol. 121, pp. 399-405.
Knoferl, M. et al. Female Sex Hormones Regulate Macrophage Function After Trauma-Hemorrhage and Prevent Increased Death Rate From Subsequent Sepsis:Annals of Surgery, Jan. 2002, vol. 235, No. 1, pp. 105-112.
Dubuquoy, L. et al. Peroxisome Proliferator-Activated Receptor (PPAR) Gamma: a New Target for the Treatment of Inflammatory Bowel Disease,Gastroenterol Clin Biol., 2000, vol. 24 No. 8-9, pp. 719-724.
Papadakis, K.A. et al. Role of Cytokines in the Pathogenesis of Inflammatory Bowel Disease:Annual Reviews, Feb. 2000, vol. 51, pp. 289-298.
Micci, M. et al. Neural Stem Cell Transplantation in the Stomach Rescues Gastric Function in Neuronal Nitric Oxide Synthase-Deficient Mice:Gastroenterology, 2005, vol. 129, pp. 1817-1824.

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