Uses of substantially pure interleukin-9 receptor

Details Uses of substantially pure interleukin-9 receptor Uses of substantially pure interleukin-9 receptor

1992-02-06

1993-01-19

Russel, Jeffrey E.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

436 63, 436503, 436504, G01N 3350, G01N 3358, G01N 3360, G01N 3368

Patent

active

051806789

ABSTRACT:
The invention relates to substantially pure interleukin 9 receptor molecules and the use thereof. The uses include use as an interleukin-9 inhibitor, as a diagnostic agent for determining interleukin-9, and as a screening agent for pharmaceuticals. The interleukin-9 receptor is characterized as a glycoprotein of about 64 kilodaltons which, upon digestion with N-glycosidase F, yields a peptide of about 54 kilodaltons.

REFERENCES:
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Fanslow et al, "Regulation of Alloreactivity in Vivo by a Soluble Form of the IL-1 Receptor," Science, May 11, 1990, vol. 248, pp. 739-742.
Schmitt et al, "TCGF III/P40 is produced by naive murine CD4.sup.+ T cells . . . ", Eur. J. Immunol. 1989, vol. 19, pp. 2167-2170.
Uyttenhove et al, "Functional and structural characterization of P40 . . . ", PNAS, Sep. 1988, vol. 85, pp. 6934-6938.
Yang et al, "Expression Cloning of a cDNA Engaging a Novel Human Hematopoietic Growth Factor . . . ", Blood, Nov. 1, 1989, vol. 74(6), pp. 1880-1884.

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