Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-06-14
2005-06-14
Wax, Robert A. (Department: 1653)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S006120, C530S324000
Reexamination Certificate
active
06905832
ABSTRACT:
The invention concerns novel uses of peptides derived from the cytoplasmic domain of the amyloid protein precursor (APP); said peptides are in particular sequences including the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP) (one-letter code), selected in the group consisting of the sequences Y1KQYTSIHHGY0(SEQ ID NO:2). Y1KKQYTSIHHGY0(SEQ ID NO:3) and Y1KKKQYTSIHHGY0(SEQ ID NO:4), wherein Y0is nil or represents V, VV, VVE, VVEV or VVVED and Y1represents an internalisation and addressing peptide, derived from the 3rdhelix of homeodomains and structurally related peptides. The invention also concerns the use of a peptide comprising the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP), for selecting and screening products capable of inhibiting apoptosis.
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Allinquant Bernadette
Prochiantz Alain
Centre National de la Recherche Scientifique "CNRS"
Morgan & Lewis & Bockius, LLP
Wax Robert A.
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