Uses of mammalian CTLA-8 and related reagents

Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 851, 530351, A61K 4505

Patent

active

060633727

ABSTRACT:
Compositions and methods for using CTLA-8 to treat an abnormal physiological condition in an individual. The methods comprise administering a therapeutically effective amount of CTLA-8 alone, or in combination with other therapeutic reagents; or a CTLA-8 antagonist.

REFERENCES:
Arthur M. Cohen, et al., Infection and Immunity, 56(11):2861-2865, Nov. 1. "In Vivo Activation of Neutrophil Funtion in Hamsters by Recombinant Human Granulocyte Colony-Stimulating Factor".
F. Fossiez, et al., 9th International Congress of Immunology, San Francisco, CA, Jul. 23-29, 1995, p. 544, see abstract No. 3222. "Human CTLA8: A Novel Cytokine With Proinflammatory Activities".
M. Krishna, et al., 37th Annual Meeting of the American Society of Hematology, Seattle Washington, USA, Dec. 1-5, 1995. Blood, 86(10 Suppl. 1):abstract 1988, Dec. 1995. A Novel Cytokine, CTLA-8 Induces Peripheral Blood Neutrophilia and Protection from Lethal Bacterial Infection in Mice.
Jens-Christian Albrecht, et al., Journal of Virology, vol. 66, No. 8, pp. 5047-5058, Aug. 1992. "Primary Structure of the Herpesvirus Saimiri Genome".
Jens-Christian Albrecht, et al., Virology, vol. 174, pp. 533-542, 1990. "Structural Organization of the Conserved Gene Block of Herpesvirus saimiri Coding for DNA Polymerases, Glycoprotein B, and Major DNA Binding Protein".
D. Caput, et al., Proc. Nat'l. Acad. Sci., vol. 83, pp. 1670-1674, Mar. 1986. "Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA moleculors specifying inflammatory mediates".
Marilyn Kozak, The Journal of Cell Biology, vol. 115, No. 4, pp. 887-903, Nov. 1991. "An analysis of Vertebrate mRNA sequences: Intimations of Translational Control".
Marilyn Kozak, J. Biol. Chem., vol. 266, No. 30, pp. 19867-19870, Oct. 1991. "Structural Features in Eukaryotic mRNAs that Modulate the Initiation of Translation".
John Nicholas, et al., Virology, vol. 179, pp. 189-200, 1990. "Gene Expression in Cells Infected with Gammaherpes-virus Saimiri: Properties of Transcripts from Two Immediate-Early Genes".
John Nicholas, et al., Gen Bank Accession No. M60286, pp. 1-3, Mar. 1991.
Marc Piechaczyk, et al., Gene, vol. 72, pp. 287-295, 1988. "Role of RNA Structures in c-myc and c-fos Gene Regulations".
Eric Rouvier, et al., The Journal of Immunology, vol. 150, No. 12, pp. 5445-5456, Jun. 1993. "CTLA-8, Cloned from an Activated T Cell, Bearing AU-Rich Messenger RNA Instability Sequences, and Homologous to a Herpesvirus Saimiri Gene".
Eric Rouvier, et al., Gen Black Accession No. L13839, pp. 1-2, Apr. 1993.
Eric Rouvier, et al., Abstract and poster presented at the International Congress of Immunology, Budapest, Hungary: abstract and poster panels, Aug. 1992. "A Search for Novel Molecules Differentially Expressed in Cytotoxic T Cells".
Gary Shaw, et al., Cell, vol. 46, pp. 659-667, Aug. 1986. "A Conserved AU Sequence from the 3'Untranslated Region of GM-CSF mRNA Mediates Selective mRNA Degradation".
Johnson, et al., Proc. Nat'l Acad. Sci. vol. 74, No. 9, pp. 3879-3884, 1977. "Pure and Mixed Erythroid Colony Formation In Vitro Stimulated by Spleen Conditioned Medium with no Detectable Erythropoietin".
A. Neil Barclay, et al., Academic Press, pp. 290-291, 1993. "The Leucocyte Antigen FactsBook".
Hyun Soon Lillehoj, et al. Eur. J. Immunol. vol. 18, pp. 2059-2065, 1988. "Functional and Biochemical Characterizations of Avian T Lymphocyte Antigens Identified by Monoclonal Antibodies,".
Sabine Muller, et al., Eur. J. Immunol. vol. 25, pp. 1744-1748, 1995. "Cloning of ATAC, an Activation-Induced, Chemokine-Related Molecule Exclusively Expressed in CD8+ T Lymphocytes".
Zhengbin Yao, et al., J. of Immunol., vol. 155, pp. 5483-5486, 1995. "Human IL-17: A Novel Cytokine Derived from T Cells".

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Uses of mammalian CTLA-8 and related reagents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Uses of mammalian CTLA-8 and related reagents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Uses of mammalian CTLA-8 and related reagents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-256286

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.