Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-08-29
2006-08-29
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S064000
Reexamination Certificate
active
07097992
ABSTRACT:
Human UDP-glucuronosyltransferase 2B7 (UGT2B7) protein expression is limited to ovarian surface epithelium cells and that this protein is not present in tumors arising from this cell layer. UDP-glucuronosyltransferase 2B7 protein accumulates in cells when the cells enter stationary phase and growth inhibition. UGT2B7 protein is not expressed in exponentially growing ovarian tumor cells. Overexpression of UGT2B7 protein in human ovarian tumor cells results in cell growth arrest, significant reduction of lipid content and changes in cell morphology. Thus, active UGT2B7 protein expression in tumor cells can be used to decrease cell proliferation and to treat various cancers, whereas UGT2B7 mRNA expression, protein expression and/or enzymatic activity can be used as a tumor specific marker in diagnostic procedures.
REFERENCES:
Radominska-Pandya et al., Arch Biochem Biophys. Mar. 1, 2002;399(1):37-48.
Czernik Piotr J.
Radominska-Pandya Anna
Adler Benjamin Aaron
Yu Misook
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