Uses of aloe products

Details Uses of aloe products Uses of aloe products

1993-12-01

1995-08-15

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

5361231, A61K 31715, C07H 108, C07H 1300

Patent

active

054419433

ABSTRACT:
Acemannan has been shown to be effective in treating a number of conditions where the principal mechanism of resolution or cure requires intervention by the patient's immune system. Acemannan has direct stimulatory effects on the immune system. Methods for treating cancer, viral diseases, respiratory and immune regulatory diseases, inflammations, infections and infestations by administering an acetylated mannan derivative, such as acemannan derived from aloe, are described. The method finds use in tissue cultures, animals and plants.

REFERENCES:
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Int. Conf. AIDS, vol. 6, No. 2, 1990, M. C. Kemp et al.: "Concentration-dependent inhibition of AIDS virus replication and pathogenesis by acemannan in vitro", p. 315, abstract No. 1007, see abstract.
Dissertation Abstracts International, vol. 52, No. 2, Aug. 1991, A. D. Chinnah et al.: "Evaluation of the antiviral, adjuvant and immunomodulatory effects of a beta-(1,4)-linked polymannose (acemannan)", p. 694-B, see abstract.
International Journal of Immunopharmacology, vol. 10, No. 8, 1988, D. Womble et al.: "Enhancement of alloresponsiveness of human lymphocytes by acemannan (Carrisyn TM)", pp. 967-974, see abstract; pp. 967-968; pp. 972-973: Discussion.
Fed. Am. Soc. Exp. Biol. J., vol. 2, No. 4, 1988, J. Measel et al.: "The effect of Carrisyn on the immune system", abstract No. 2239, see abstract.
Antiviral Res. O., suppl. 1, 1990, M. C. Kemp et al.: "In vitro evaluation of the antiviral effects of acemannan on the replication and pathogenesis of HIV-1 and other enveloped viruses: modification of the processing of glycoprotein precursors", p. 83, abstract No. 84, see abstract.
Antiviral Res. O., suppl. 1, 1990, H. R. McDaniel et al.: "Extended survival and prognostic criteria for acemannan (ACE-M) treated HIV-1 patiens(pts)", p. 117, abstract No. 147, see abstract.
American Journal of Clinical Pathology, vol. 88, No. 4, Oct. 1987, H. Reg. McDaniel et al.: "A clinical pilot study using Carrisyn TM in the treatment of acquired immunodeficiency syndrome (AIDS)", p. 534, see abstract.
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Mol. Biother., vol. 3, No. 1, Mar. 1991, M. A. Sheets et al.: "Studies of the effect of acemannan on retrovirus infections: clinical stabilization of feline leukemia virus-infected cats", pp. 41-45, see abstract; pp. 41-42, 44-45.
Mol. Biother., vol. 3, No. 2, Jun. 1991, S. Y. Peng et al.: "Decreased mortality of norman murine sarcoma in mice treated with the immunomodulator, acemannan TM", pp. 79-87, see abstract; pp. 79-80, 85-86.
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