Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1988-06-29
1990-03-27
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 3119
Patent
active
049121367
ABSTRACT:
Although fenclofenac (2-(2,4-dichloro-phenoxy) phenyl acetic acid) is known as an NSAID it has now been shown to have immunosuppressive properties indicating its usefulness in the treatment of a wide variety of conditions requiring immunosuppressive therapy. In this role fenclofenac may be combined with a prostaglandin and/or another immunosuppressive drug, and may be administered in a form for release in the terminal ileum or colon.
REFERENCES:
Dunagan, F. M. et al, "Quantitation of Dose and Concentration-Effect Relationships for Fenclofenac in Rheumatoid Arthritis", Br. J. Clin. Pharmac. (1986), 21, 409-416.
Katona, G., "Fenclofenac: A New Nonsteroidal Antiinflammatory Drug with an Immunomodulatory Effect in The Treatment of Active Rheumatoid Arthritis", Current Therapeutic Research, vol. 37, No. 1, Jan. 1985, pp. 58-69.
Atkinson et al, Agents & Actions, 6,(5), 657-666 (1976) Anti-Inflammatory and Related Properties of 2-(2,3-dichlorophenoxy) Phenylacetic Acid (Fenclofenac).
Phillips, N. C., "Immuno-Inflammatory Pharmacology of Fenclofenac: A Preliminary Report", Royal Society of Medicine, Series No. 28, 1980, pp. 83-88, Academic Press and Grune and Stratton, London.
Matheus, P. C. et al, Brazilian Congress of Rheumatology, Recife, Jul. 1982, reported in Rev. Bras. Reumat. 22 (3) 139 (1982), "The Effect of Fenclofenac on Cellular Immunity".
Ku, E. C. et al, "The Effects of Diclofenac Sodium on Arachidonic Acid Metabolism", Seminars in Arthritis and Rheumatism, 15, 2, Suppl. 1, 36-41 (1985).
Friedman Stanley J.
Reynolds Florence U.
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