Uses for antibodies which bind to human somatomedin carrier prot

Details Uses for antibodies which bind to human somatomedin carrier prot Uses for antibodies which bind to human somatomedin carrier prot

1995-05-12

1997-04-29

Chin, Christopher L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436501, 530395, 530412, G01N 3353, G01N 33566, C07K 100

Patent

active

056248059

ABSTRACT:
This invention relates to polypeptides that are human somatomedin carrier protein subunits and to processes for producing them. The carrier protein subunits bind to human somatomedin-like polypeptides, also known as insulin-like growth factors. The process involves preparation from a human serum fraction, Cohn IV-1, by a molecule of various chromatographic steps.
This invention also relates to DNA molecules encoding human somatomedin carrier protein-like polypeptides, recombinant DNA molecules, hosts, processes for producing carrier protein-like polypeptides, human somatomedin carrier protein-like polypeptides produced using those molecules, hosts and processes. The invention relates to DNA molecules and their expression in appropriate hosts. The recombinant DNA molecules contain DNA molecules that code for polypeptides which have a biological activity of the human carrier protein or a human carrier protein subunit capable of binding somatomedins. The DNA molecules, recombinant DNA molecules, hosts, and processes of this invention may be used in the production of polypeptides useful in a variety of therapeutic, diagnostic, and other useful applications.

REFERENCES:
patent: 4394443 (1983-07-01), Weissman et al.
patent: 4642120 (1987-02-01), Nevo et al.
patent: 4703004 (1987-10-01), Hopp et al.
patent: 4727028 (1988-02-01), Santerre et al.
patent: 4738921 (1988-04-01), Belagaje et al.
patent: 4861757 (1989-08-01), Antoniades et al.
patent: 4885163 (1989-12-01), Shaar et al.
patent: 5084384 (1992-01-01), Wong et al.
patent: 5104796 (1992-04-01), Keith et al.
patent: 5200509 (1993-04-01), Spencer et al.
patent: 5258287 (1993-11-01), Baxter et al.
patent: 5328891 (1994-07-01), Baxter et al.
Chatelain, P.G. et al. J. Clin. Endocrinol. Metab. 56(2):376-383 (1983).
Clemmons, D.R. et al. J. Clin. Endocrinol. Metab. 56(2):384-389 (1983).
Scott, C.D. et al. Endocrinology 116(3):1094-1101 (1985).
Romanus, J.A. et al. Endocrinology 118(5): 1743-1758 (1986).
Abstract of Brewer et al., "Cloning, characterization, and expression of a human insulin-like growth factor binding protein" Biochem. Biophys. Res. Comm. (1988) 152:1289-1297.
Abstract of Brinkman et al., "Isolation and characterization of a complementary DNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)" EMBO J. (1988) 7:2417-2424.
Abstract of Internatioal (PCT) Patent Publication No. WO 88/09818 (Dec. 15, 1988).
Morris et al., "Structure of somatomedin-binding protein: Alkaline pH-induced dissociation of an acid-stable, 60,000 molecular weight complex into smaller components" Endocrinol. (1982) 111:801-805.
Abstract of Furlanetto et al., "The somatomedin C binding protein: Evidence for a heterologous subunit structure" J. Clin. Endocrinol. Metab. (1980) 51:12-19.
Zapf et al., "Isolation and NH.sub.2 -terminal amino acid sequences of rat serum carrier proteins for insulin-like growth factors" Biochem. Biophys. Res. Comm. (1988) 156:1187-1194.
Abstract of International (PCT) Patent Publication No. WO 89/09792 (Oct. 19, 1989).
Abstract of International (PCT) Patent Publication No. WO 89/08666 (Sep. 21, 1989).
Smith, G.L., "Review-Somatomedin carrier proteins" Mol. Cell. Endocrinol. (1984) 34:83-89.
Drop et al., "Immunoassay of a somatomedin-binding protein from human amniotic fluid: Levels in fetal, neonatal, and adult sera" J. Clin. Endocrinol. Metab. (1984) 59:908-915.
Gourmelen et al., "Serum levels of insulin-like growth factor (IGF) and IGF binding protein in constitutionally tall children and adolescents" J. Clin. Endocrinol. Metab. (1984) 59:1197-1203.
Wood et al., "Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein" Mol. Endocrinol. (1988) 2:1176-1185.
Baxter et al., "Growth hormone-dependent insulin-like growth factor (IGF) binding protein from human plasma differs from other human IGF binding proteins" Biochem. Biophys. Res. Comm. (1985) 139:1256-1261.
Baxter et al., "Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma" J. Clin. Invest. (1986) 78:1504-1512.
Martin et al., "Insulin-like growth factor-binding protein from human plasma purification and characterization" J. Biol. Chem. (1986) 261:8754-8760.
Scheiwiller et al., "Growth restoration of insulin-deficient diabetic rats by recombinant human insulin-like growth factor I" Nature (1986) 323:169-171.
Koistinen et al., "Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid" Endocrinol. (1986) 118:1375-1378.
P ovoa et al., "The somatomedin-binding protein isolated from a human hepatoma cell line is identical to the human amniotic fluid somatomedin-binding protein" Biochem. Biophys. Res. Comm. (1985) 128:1071-1078.
Schmid et al., "Intact but not truncated insulin-like growth factor binding protein-3 (IGFBP-3) blocks IGF I-induced stimulation of osteoblasts: Control of IGF signalling to bone cells by IGFBP-3-specific proteolysis?" Biochem. Biophys. Res. Comm. (1991) 179:579-585.
Yee et al., "Insulin-like growth factor binding protein 1 expression inhibits insulin-like growth factor I action in MCF-7 breast cancer cells" Cell Growth & Differentiation (1994) 5:73-77.
Sommer et al., "Molecular genetics and actions of recombinant insulin-like growth factor binding protein-3" Modern Concepts of Insulin-Like Growth Factors(1991) Spencer, E.M., ed., Elsevier Science Publishing Co., Inc. New York, pp. 715-728.
Sommer et al., "Properties of glycoslyated and non-glycoslyated human recombinant IGF binding protein-3 (IGFBP-3)" Growth Regulation (1993) 3:46-49.
Kalu, "The ovariectomized rat model of postmenopausal bone loss" Bone and Mineral (1991) 15:175-192.
Frost et al., "On the rat model of human osteopenias and osteoporoses" Bone and Mineral (1992) 18:227-236.
Spencer et al., "Somatomedins: Do they play a pivotal role in wound healing?" Growth Factors and Other Aspects of Wound Healing: Biological and Clinical Implications (1988) Alan R. Liss, Inc., pp. 103-116.
Steenfos et al., "Growth hormone stimulates granulation tissue formation and insulin-like growth factor-I gene expression in wound chambers in the rat" J. Endocrinol. (1992) 132:293-298.
Lawrence et al., "The reversal of an Adiramycin.RTM. induced healing impairment with chemoattractants and growth factors" Ann. Surg. (1986) 203:142-147.
Grotendorst et al., "Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats" J. Clin. Invest. (1985) 76:2323-2329.
Goodson III et al., "Development of a new miniature method for the study of wound healing in human subjects" J. Surg. Res. (1982) 33:394-401.
Bentley et al., "Peptides from live yeast cell derivative stimulate wound healing" Arch. Surg. (1990) 125:641-646.
Martin et al., "Antibody against acid-stable insulin-like growth factor binding protein detects 150,000 mol wt growth hormone-dependent complex in human plasma" J. Clin. Endocrinol. Metabol. (1985) 61:799-801.
Spencer et al., "Isolation of the human plasma carrier protein for somatomedin" Abstracts, 7th International Congress of Endocrinology (1984) p. 1278 (Abstract 2036).
Baxter et al., "Purification and radioimmunoassay of insulin-like growth factor binding protein from human plasma" The Endocrine Society, 67th Annual Meeting (Jun. 19-21, 1985) p. 201.
Grant et al., "Separation of the insulin-like growth factor binding proteins in human serum and charaterization of the acid stable component of the 150K species" The Endocrine Society, 68th Annual Meeting (Jun. 25-27, 1986) p. 83.
Gelato et al., "Heterogeneity of insulin-like growth factor (IGF) binding protein species derived from the M.sub.r =150 K IGF-binding protein complex" The Endocrine Society, 68th Annual Meeting (Jun. 25-27, 1986) p. 83.
Kuffer et al., "Partial purification of a specific inhibitor of the insulin-like growth factors by reversed-phase high-performance liquid chromatography" J. Chromatography (1984) 336:87-92.
Knauer et al., "Purification and characte

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