Uses for amino acid anticonvulsants

Details Uses for amino acid anticonvulsants Uses for amino acid anticonvulsants

2005-04-26

2005-04-26

Weber, Jon (Department: 1653)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S567000, C562S575000

Reexamination Certificate

active

06884910

ABSTRACT:
The present invention is directed to the use of compounds of the formula:for treating pain, in particular neuropathic pain, bipolar disease and migraine headaches.

REFERENCES:
patent: 4510082 (1985-04-01), Gesellchen et al.
patent: 4518587 (1985-05-01), Laruelle et al.
patent: 4533657 (1985-08-01), Morgan
patent: 4707468 (1987-11-01), Yoshino et al.
patent: 5378729 (1995-01-01), Kohn et al.
patent: 5508266 (1996-04-01), Fink
patent: 5654301 (1997-08-01), Kohn et al.
patent: 5773475 (1998-06-01), Kohn
patent: 5780589 (1998-07-01), Lazarus et al.
patent: 5885999 (1999-03-01), Elliot et al.
patent: 6037324 (2000-03-01), Schwender et al.
patent: 6126939 (2000-10-01), Eisenbach-Schwartz et al.
patent: 6133261 (2000-10-01), Harris
patent: 6180611 (2001-01-01), Montana et al.
patent: 6228875 (2001-05-01), Tsai et al.
patent: 6737408 (2004-05-01), Balasubramanium et al.
patent: 0 997147 (1998-07-01), None
patent: 1 084 704 (2001-03-01), None
patent: WO 9903460 (1999-01-01), None
patent: WO 9943309 (1999-09-01), None
patent: 985940 (1998-07-01), None
Raffa Robert B, Rheumatic diseases clinics of North America, (Nov 2003) 29 (4) 733-45.*
Schaible Hans-Georg, Annals of the New York Academy of Sciences, (Jun 2002) 966 343-54.*
Lowry, Thomas (Mechanism and Theory in Organic Chemistry, pp. 60-71, Harper & Row, New York, 1976).*
Ritchie, Prog Phys Org Chem, vol 2, 323, 1964.*
Konttinen Y. T. (Arthritis and rheumatism 37 (7) 965-82, 1994).*
Kidd B. L., British Journal of Anaesthesia, (Jul 2001) 87 (1) 3-11.*
Shimohigashi, J Biol. Chem. 271, 23642, 1996.*
Kohn H. et al., “Synthesis and anticonvulsant activities of α-heterocyclic α-acetamido-N-benzylacetamide derivatives”,Journal of Medicinal Chemistry, United StatesOct. 29, 1993, vol. 36, No. 22, pp. 3350-3360, ISSN: 0022-2623, p. 3355, col. 1, paragraph 2, example 3F; table 1.
Shridhar V. Andurkar, et al., “The Anticonvulsant Activities of N-Benzyl 3-Methoxypropionamides”, Bioorganic & Medicinal Chemistry 7 (1999), pp. 2381-2389, p. 2381, col. 2; example 3, p. 2385, col. 1, paragraph 2-paragraph 3, XP001097157.
Claudio Toniolo, et al., “A crystal-state, solution and theoretical study of the preferred conformation of linear C.α,α-diphenylglycine derivatives and dipeptides with potential anticonvulsant activity”,Int. J. Pept. Protein Res. 44.1994, 85-95, XP001074241, , p. 85, col. 1, paragraph 2, p. 86, col. 1; example XIV.
Claudio Toniolo, et al., “A crystal-state, solution and theoretical study of the preferred conformation of linear C.α,α-diphenylglycine derivatives and dipeptides with potential anticonvulsant activity”,Int. J. Pept. Protein Res. 44.1994, 85-95, XP001074241,, p. 85, col. 1, paragraph 2, p. 86, col. 1; example XIV.
Solomon H. Snyder, et al., D-Amino Acids as Putative Neurotransmitters: Focus on D-Serine,Neurochemical Research,vol. 25, No. 5, 2000, pp. 553-560.
Abstract of International Application No. WO 99/02146 dated Jan. 21, 1999.
David E. Baranan et al., “Atypical neural messengers”,TRENDS in Neurosciences,vol. 24, No. 2, Feb. 2001, pp. 99-106.
J.M. Elliott, et al., “Serine Derived NK, Antagonists 1: The Effect of Modifications to the Serine Substituents”,Bioorganic&Medical Chimistry Letters 8(1998) pp. 1845-1850.
Solomon H. Snyder, M.D., et al., “Novel Neurotransmitters and their Neuropsychiatric Relevance”,Am J Psychiatry, 157:11,Nov. 2000, pp. 1738-1751.
Robert Berkow, M.D., et al., “The Merck Manual of Diagnosis and Therapy”,Merck Research Laboratories, (1992), pp. 1406-1615.
Harris FRC, and Schwarz Pharma AG,Windover Information Inc.,2000, p. 122.
Herman Wolosker, et al., “Serine racemase: A glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-asparatate neurotransmission”,PNAS,vol. 96, No. 23, Nov. 9, 1999, pp. 13409-13414.
Daeock Choi, “Synthesis, Chemistry, and Biological Evaluation of Medicinally Relevant Compounds”,A Bell&Howell Company, Dec.,1995, pp. 1-208.
Fu Y, et al., “Systemic nicotine stimulates dopamine release in nucleus accumbens: Re-evaluation of the role of N-methyl-D-aspartate receptors in the ventral tegmental area”,J Pharmacol Exp Ther2000,294(2):458-65.
Kohn H. et al., “Synthesis and anticonvulsant activities of α-heterocyclic α-acetamido-N-benzylacetamide derivatives”,Journal of Medicinal Chemistry, United StatesOct. 29, 1993, vol. 36, No. 22, pp. 3350-3360.
Andurkar, et al., “The Anticonvulsant Activities of N-Benzyl 3-Methoxypropionamides”, Bioorganic & Medicinal Chemistry 7 (1999), pp. 2381-2389.
Toniolo, et al., “A crystal-state, solution and theoretical study of the preferred conformation of linear C.α,α-diphenylglycine derivatives and dipeptides with potential anticonvulsant activity”,Int. J. Pept. Protein Res. 44.1994, 85-95, XP001074241, , p. 85, col. 1, paragraph 2, p. 86, col. 1; example XIV.
Billich, et al., “HIV proteinase inhibitors containing 2-aminobenzylstatine as a novel scissile bond replacement: biochemical. and pharmacological characterization”,Antiviral Research 25(1994) pp. 215-233.
Parsons, et al., “Modulation of NMDA receptors by glycine—introduction to some basic aspects and recent developments”,Amino Acids, 14: 207-216 (1998).
Wlaz, et al., “Anticonvulsant effects of eliprodil alone or combined with the glycineBreceptor antagonist L-701,324 or the competitive NMDA antagonist CGP 40116 in the amygdala kindling model in rats”,Neuropharmacology, 38: 243-251 (1999).
Ebert, et al., “Anticonvulsant effects by combined treatment with a glycineBreceptor antagonist and a polyamine site antagonist in amygdala-kindled rats”,European Journal of Pharmacology, 322: 179-184 (1997).

Affiliated with

Also associated with

Rating

Uses for amino acid anticonvulsants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Uses for amino acid anticonvulsants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Uses for amino acid anticonvulsants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3423999