Useful indole compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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C544S335000, C546S113000, C546S115000, C546S278100, C548S131000, C548S143000, C548S159000, C548S204000, C548S217000, C548S236000, C548S248000

Reexamination Certificate

active

07960544

ABSTRACT:
Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.

REFERENCES:
patent: 3856967 (1974-12-01), Allais et al.
patent: 3946029 (1976-03-01), Descamps et al.
patent: 4105777 (1978-08-01), Allais et al.
patent: 4233312 (1980-11-01), Allais et al.
patent: 6069156 (2000-05-01), Oku et al.
patent: 2002/0022218 (2002-02-01), Li et al.
patent: 2003/0162825 (2003-08-01), Heefner et al.
patent: 2007/0203209 (2007-08-01), Bartolini et al.
patent: 2009/0118503 (2009-05-01), Sprott et al.
patent: WO 03/022274 (2003-03-01), None
patent: WO03066047 (2003-08-01), None
patent: WO2006036994 (2006-04-01), None
patent: WO2007/022501 (2007-02-01), None
Drew et al. J. Chem. Crystallogr. (2008) 38: 507-512.
STN Registry file record for RN 501659-75-2. Entered STN Apr. 4, 2003. Accessed database entry on Jun. 21, 2010.
Ajuebor et al., “Cyclooxygenase-2-derived prostaglandin D2 is an early anti-inflammatory signal in experimental colitis,” Am. J. Physiol. Gastrointest. Live Physiol., 279:G238-G244, 2000.
Arora and Yamazaki, “Eosinophilic Esophagitis: Asthma of the Esophagus?” Clinical Gastroenterology and Heptology, 2:523-530, 2004.
Black et al., “From lodomethacin to a Selective Cox-2 Inhibitors,” Bioorganic & Medicinal Chemistry Letters, 6(6): 725-730, 1996.
Chen et al., “Flavoenzymes Inhibited by Indomethacin,” Drug Metabolism and Drug Interactions, 11(2): 153-160, 1994.
Cravatt and Lichtman, “Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system,” Current Opinion in Chemical Biology, 7:469-475, 2003.
Deutsch et al., “The fatty acid amide hydrolase (FAAH),” Prostaglandins, Leukotrienes and Essential Fatty Acids, 66 (2&3): 201-210, 2002.
Duggan et al., “Metabolism of Indomethacin in Man,” The Journal of Pharmacology, 181: 563-575, 1972.
Fride and Mechoulam, “Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent,” European Journal of Pharmacology, 231: 313-314, 1993.
Harman et al., “The Metabolites of Indomethacin, A New Anti-Inflammatory Drug,” The Journal of Pharmacology, 143: 215-220, 1964.
Hecht et al., “Heterologous desensitization of T cell functions by CCR5 and CXCR4 ligands: inhibition of cellular signaling, adhesion and chemotaxis,” International Immunology, 15(1): 29-38, 2003.
Helleberg, Lars, “Clinical Pharmacokinetics of Indomethacin,” Clinical Pharmacokinetics, 6: 245-258, 1981.
Huang et al., “Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability,” Human Molecular Genetics, 13(21): 2691-2697, 2004.
Kiehl et al., “Tissue eosinophilia in acute and chronic atopic dermatitis: a morphometric approach using quantitative image analysis of immunostaining,” British Journal of Dermatology, 145: 720-729, 2001.
Lau et al., “From Indomethacin to a Selective Cox-2 Inhibitor: Development of Indolalkanoic Acids as Potent and Selective Cyclooxygenase-2 Inhibitors,” in: Honn et al., Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3, (New York, Plenum Press), 73-78, 1997.
Monneret et al., “15R-Methyl-Prostaglandin D2 is a potent and selective CRTH2/DP2 Receptor Agonist in Human Eosinophils,” The Journal of Pharmacology and Experimental Therapeutics, 304(1): 349-355, 2003.
Nagata et al., “CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s),” FEBS Letters, 459: 195-199, 1999.
Shen and Winter, “Chemical and Biological Studies on Indomethacin, Sulindac and their Analogs,” in: Harper and Simmonds, Advances in Drug Research, vol. 12 (London Academic Press), 89-245, 1977.
Shen et al., “Non-Steroid Anti-Inflammatory Agents,” Communications to the Editor, 85: 488-489, 1963.
Shichijo et al., “Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Activation in Vivo Increases Book Leukocyte Counts and Its Blockge Abrogats 13,14-Dihydro-15-keto-prostagladin D2-Induced Eosinophilia in Rats,” The Journal of Pharmacology and Experimental Therapeutics, 307(2): 518-525, 2003.
Strachan et al., “Synthesis of Indomethacin Metabolites,” Notes, 799-800, 1964.
Stubbs et al., “Indomethacin Causes Prostaglandin D2-like and Eotaxin-like Selective Responses in Eosinophils and Basophils,” The Journal of Biological Chemistry, 277(29): 26012-26020, 2002.
Touhey et al., “Structure-activity relationship of indomethacin analogues for MRP-1, COX-1 and COX-2 inhibition: identification of novel chemotherapeutic drug resistance modulators,” European Journal of Cancer, 38: 1661-1670, 2002.
Walker et al., “Pain modulation by release of the endogenous cannabinoid annadamide,” PNAS, 96(21): 12198-12203, 1999.
Weber et al., “Formation of prostamides from anadamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry,” Journal of Lipid Research, 45: 757-763, 2004.
Yoshimura-Uchiyama et al., “Differential modulation of human basophil functions through prostaglandin D2-receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2,” Clin. Exp. Allergy, 34: 1283-1290, 2004.

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