Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai
Patent
1991-01-18
1992-08-04
Friedman, S. J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ortho-hydroxybenzoic acid or derivative doai
514404, 514420, 514494, A61K 3140, A61K 21315, A61K 31415, A61K 31605
Patent
active
051359251
ABSTRACT:
Zinc acexamate acts by increasing the synthesis of mucus, reinforces the mucous barrier, improves the microcirculation and increases the synthesis of prostaglandins in the gastric mucous membrane, whereby it is effective in the treatment of said gastropathy, contrary to the results obtained with antiacids or antisecretory agents.
REFERENCES:
European Journal of Pharmacology-vol. 109, 1985, pp. 145-151 Esplugues et al. "Effects of Zinc Acexamate on Gastric Mucosal Resistance Factors".
Prostaglandins, Leukotrienes & Essential Fatty Acids, vol. 33, 1988 pp. 75'80, Longman Group Ltd., GB "Effects of zinc acexamate on gastric muscosal production of prostaglandin E2 in normal and stressed rats".
Meth. and Find. Exptl. CliniPharmaca Col. vol. 9, No. 7, 1987, pp. 423-427 G. Escolar et al., "Antiulcerogenic Activity of Zinc Acexamate in Different Experimental Models".
Postgraduate Medical Journal, vol. 64, (Suppl. 1), 1988 pp. 12-14 M. M. Cohen "Aspirin-induced gastrodnodeaal injury and its prevention by prostaglandins".
Chemical Abstracts, vol. 99, No. 10, 1983, p. 370, ref. 76901j Carpov et al. "Antiinflammatory and antirheumatic composition containing acetylsalicylic acid and aminocaproic acid".
Arch. Intern. Med., vol. 146, Jun. 1986, pp. 1075-1076, S. H. Roth "Nonsteroidal Anti-inflammatory Drug Gastropathy".
Chem. Abst. 105-145966R (1986).
Chem. Abst. 106-188991H (1987).
Friedman S. J.
Laboratorios Vinas S.A.
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