Use of Zeranol to modulate reproductive cycles

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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A61K 3156

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060873523

ABSTRACT:
This invention relates to a method for modulating the function of the reproductive system in female animals, especially farm animals, and specifically in horses and pigs, by administering an effective amount of zeranol. Specifically, this invention provides a method for maintaining corpus luteum function, especially in pigs and horses, by administering an effective amount of zeranol.

REFERENCES:
patent: 3989828 (1976-11-01), Aries
patent: 4192870 (1980-03-01), Grandadam et al.
patent: 4239772 (1980-12-01), Shipchandler
patent: 4443470 (1984-04-01), Hodge et al.
patent: 4886899 (1989-12-01), Jacobs
patent: 5210225 (1993-05-01), Moimas et al.
patent: 5314882 (1994-05-01), Pantic et al.
patent: 5593978 (1997-01-01), Jacobs et al.
patent: 5674892 (1997-10-01), Giese et al.
patent: 5728726 (1998-03-01), Giese et al.
Deutscher, G.H., et al., "Time of Zeranol Implantation on Growth, Reproduction and Calving of Beef Heifers", J. Anim. Sci. 62:875-886, 1986.
Staigmiller, R.B., et al., "Growth and Reproductive Traits in Beef Heifers Implanted with Zeranol", J. Anim. Sci., 57:527-534, 1983.
Frank, M., et al., "A Study of Prostaglandin F.sub.2.oe butted. as the Luteolysin in swine: III Effects of Estradiol Valerate on Prostaglandin F, Progestins, Estrone and Estradiol Concentrations in the Utero-Ovarian Vein of Nonpregnant Gilts", Prostaglandins 14:1183-1196, 1977.
Kraeling, R., et al. "Prostaglandins-Induced Regression of Porcine Corpora Lutea Maintained by Estrogen", Prostaglandins 9:459-462, 1975.
Mirocha, C., et al., Zearalenone. In: J.V. Rodricks, C.W. Hessltine and M.A. Mehlam (eds.) Micotoxins in Human and Animal Health. Pathotox Publications Inc., Forest Park South, Il. 345-364, 1977.
Love, R.J., et al. "Seasonal effects on fertility in gilts and sows", J. Reprod. Fertil. (Suppl. 48):191-206, 1993.
Geisert, R.D., et al. "Length of pseudopregnancy and pattern of uterine protein release as influenced bt time and duration of oestrogen administration in the pig", J. Reprod. Fertil. 79:163-172, 1987.
Zavy, M.T., et al., "Estrogen-Induced Pseudopregnancy in Gilts: Its Use in Estrus Synchronization and Subsequent Influence on Litter Response", Theriogenol. 30:721-732, 1988.
Guthrie, H.D., "Estrous Synchronization and Fertility in Gilts Treated with Estradiol-Benzoate and Prostaglandin F.sub.2.oe butted. ", Theriogenol. 4:69-75, 1975.
Pusateri, A.E., et al. "Maternal Recognition of Pregnancy in Swine. 1. Minimal Requirement for Exogenous Estradiol-17.beta.to Induce Either Short or Long Pseudopregnancy in Cycling Gilts", Biol. Reprod. 55:582-589, 1996.
Stob, M. et al., "Isolation of an Anabolic, Uterotrophic Compound from Corn infected with Gibberella zeae"Nature 196:1318, 1962.
Lindsay, D.G., "Zeranol-A `Nature-Identical`Oestrogen?", Fd. Chem. Toxic. 23:767-774, 1985.
Etienne, M. and Jemmali, M., "Effects of Zearalenone (F2) on Estrous Activity and Reproduction in Gilts", J. Anim. Sci. 55:1-10, 1982.
Young, L.G. and King, G.J., "Low Concentrations of Zearalenone in Diets of Mature Gilts", J. Anim. Sci. 63:1191-1196, 1986.
Flowers, B. et al., "A Comparison of Effects of Zearalenone and Estradiol Benzoate on Reproductive Function During the Estrous Cycle in Gilts", J. Anim. Sci. 65:1576-1584, 1987.
Katzenellenbogen, B., et al., "Zearaenones: Characterization of the Estrogenic Potencies and Receptor Interactions of a Series of Fungal .beta.-Resorcylic Acid Lactones", Endocrinol. 105:33-40, 1979.
Denzer, et al., "Evalution of Growth, Carcass Traits and Reproduction Organs of young Boars in Response to Zeranol Implantation", J. Anim. Sci. 62:1164-1171, 1986.
Brown, R.G., Ralgro Manual: Toxicology and Tissue residues of Zeranol. International Mineral and Chemical Corp. (Pub. Date Unknown).
Weekley, K.A.,"Nutritional management, breed of sire and zeranol effects on growth and reproductive traits in Bos taurus x Bos indicus beef heifers", M.S. Thesis, University of Florida 1991 (Title only, no abstract).
Khodabandeholu, H., et al. "Investigations on the occurence and content of oestrogenic activity in cattle feed in the state of Central Hessia, Germany", Deutsche Tieraerztliche Wochenschrift, 104:291-294, 1997 (Abstract).
Vanyi, A., et al., "Reproductive disorders due to F-2 and T-2 toxins in large scale pig farms", Magyar Allatorvosok Lapja, 50:424-430, 1995 (Abstract), Biological Abstract 100:8(127650).
Robert G., et al. "More important mycotoxicoses in pigs. Comprehensive clinico-pathological communication", Magyar Allatorvosok Lapja, 50:407-420, 1995 (Abstract), Biological Abstract 100:8(127649).
Etienne, M., et al. "Effects of zearalenone or glucosinolates in the diet on reproduction in sows: A review", Liverstock Production Science, 40:99-113, 1994 (Abstract).
Marshall, T.T., et al. "Effects of zeranol on postweaning development and reproduction of beef heifers", J Dairy Sci, 72:464-465, 1989 (Title only, no abstract).
Khodabandehlou, H., et al., "Investigation of oestrogenic activity in cattle feeds in Central Hessia, Germany", Deutsche Tierarztliche Wochenschrift, 104:291-294, 1997 (Abstract).
Kramer, R., et al., "Free and conjugated levels of zearalenone in ewes mated on grass-dominant pasture or chicory", Proceesings of the New Zealand Society of Animal Production, 57:190, 1997 (Abstract).
Lusky, K., et al., "Simultaneous administration of the mycotoxins ochratoxin A and zearalenone to pigs in the feed. Effect on health, and tissue residues", Tierarztliche Umschau, 52:212-216, 221, 1997 (Abstract).
Renaville, R., et al., "Aspects on the use of anabolic steroids in animal production", Scientific conference on growth promotion in meat production. Proceedings, Brussels, Belgium, Nov. 29 to Dec. 1, 1995, 63-86, 1996 (Abstract).
Hargrove, D.D., "Use of growth promotions in replacements heifers", In Factors affecting calf crop., Editor, Fields, M.J., et al. pp. 91-104, 1994, Boca Raton, Florida (Abstract).
Williams, K.C., et al., "Effect of the mycotoxins, nivalenol and zearalenone, in maize naturally infected with Fusarium graminearum on the performance of growing and pregnant pigs", Australian Journal of Agricultural Research, 45:1265-1279, 1994 (Abstract).
Wolf, H., et al., "Observation on the effect of Fusarium toxins on fertility and litter size in sows.", Monatshefte fur Veterinarmedizin, 49:207-211, 1994 (Abstract).
Towers, N.R., "Zearalenone induced infertility in sheep", Publication-Veterinary Continuing Education, Massey, Proc. 22.sup. seminar, Sheep & Beef Cattle Soc., 145:159-178, 1992 (Abstract).
Kirkwood, R.N., et al., "The influence of zeranol implantation on growth and reproduction in heifers", Canadian Journal of Animal Science, 71:1253-1256, 1991 (Abstract).
Makarechian, M., et al., "Effect of postweaning implantation of zeranol and dietary energy level on growth and reproductive performance of replacement beef heifers", Canadian Journal of Animal Science, 71:265-270, 1996 (Abstract).
Libal, G.W., "Feeding sows to maximize reproductive and lactation capabilities", Swines nutrition (edited by Miller, E., et al.), Nutrition Abstract & Reviews: Series B Livestock Feds & Feeding, 62:527-555, 1991 (Abstract).
Moran, C., et al., "The effect of chronic exposure to androgens and oestrogens on development of mammary glands and reproduction tracts in heifers", 11.sup.th International Congress on Animal Reproduction and Artifical Insemination, University College Dublin, Ireland, Jun. 26-30, 4:3, 1988 (Abstract).
Kordic, B., et al., "Effect of low doses of the mycotoxin zearalenone on the reproductive characteristics of pigs", Veterinarski Glasnik, 44:151-155, 1990 (Abstracts).
Cohen, R.D.H., et al., "Effect of repeated implantation with zeranol from birth or weaning on growth and reproduction in beef heifers", Canadian Journal of Animal Science, 67(1) 37-42, 1987 (Abstract).
Yang, H.H., et al., "Effects of zearalenone and/or tamoxifen on swine and mink reproduction", J. Appl Toxicol, 15:223-32, 1995 (Abstract).
Ito, Y., et al., "Effects of neonatal administration of zearalenone on the reproductive physiology of female mice", J Vet Med Sci, 56:115-9, 1994 (Abstract).
Kordic, B., et al.

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