Use of yeast homologous signals to secrete heterologous proteins

Details Use of yeast homologous signals to secrete heterologous proteins Use of yeast homologous signals to secrete heterologous proteins

1990-06-20

1991-04-23

Teskin, Robin L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 695, 435 6951, 4351723, 435320, 435255, 435256, 435 691, 435 698, 536 27, 935 37, 935 47, 935 48, C12P 2100, C12P 2102, C12N 1500

Patent

active

050100033

ABSTRACT:
Described herein is the secretion from yeast of heterologous protein via a preprotein in which the heterologous protein is fused to the signal peptide of a yeast protein. The preprotein is processed by the cells to produce and secrete mature heterologous protein.

REFERENCES:
patent: 4338397 (1982-07-01), Gilbert et al.
patent: 4546082 (1985-10-01), Kurjan et al.
Thomer from "The Molecular Biology of the Yeast Succharomyces", Strathern et al., Editors, pp. 161-163, 1981.
Carlson et al., Cell, vol. 28, pp. 145-154, 1982, "Two Differentially Regulated mRNAs with Different 5' End & Encode Secreted and Intracellular Forms of Yeast Intervase."
Hitzeman et al., Science, vol. 219, Feb. 11, 1983, pp. 620-625, "Secretion of Human Interferons by Yeast".
Talmadge et al., Nature, vol. 294, p. 176, 1981.
Tuite et al., EMBO Journal, vol. 1(5), pp. 603-608, 1982, "Regulated High Efficiency Expression of Human Interferon-Alpha in Succharoinyces".
Hitzeman et al., J. Biol. Chem., vol. 255(24), 12-25-80, pp. 12073-12080, "Isolation and Characterization of the Yeast 3-phosphoglycerokinase Gene (PGK), by an Immun. Screening Technique".
Hitzeman et al., Nature, vol. 293, (5835), pp. 717-722, Oct. 29, 1981, "Expression of a Human Gene for Interfoning Yeast".
Davis et al., Nature, vol. 2836, pp. Jan. 31, 1980, "The Mechanism of Protein Secretion across Membranes".
Silhavy et al., Micro. Rev., Sep. 1983, vol. 47(3), pp. 313-344, "Mechanisms of Protein Localization".
Talmadge et al., Proc. Natl. Acad. Sci., vol. 77(6), Jun. 1980, pp. 3369-3373, "Eukaryotic Signal Sequence Transports Insulin Antigen in E. coli".
Kadonaga et al., J. Biol. Chem., vol. 259(4), Feb. 25, 1984, pp. 2149-2154, "The Role of the .beta.-lactamase Signal Sequence in the Secrection of Proteins by E. coli".
Bassford et al., J. Bact., vol. 137(1), Jul. 1979, pp. 19-31, "Use of Gene Fusion to Study Secretion of Maltose-Binding Protein into E. coli Periplasm".
Kurjan, J. et al., "Cell", 30:933-943, (Oct. 1982).
Perlman, D. et al., "Proc. Natl. Acad. Sci. U.S.A.", 79:781-785, (Feb. 1982).

Affiliated with

Also associated with

Rating

Use of yeast homologous signals to secrete heterologous proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of yeast homologous signals to secrete heterologous proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of yeast homologous signals to secrete heterologous proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1621083