Use of xanthine derivatives for the modulation of apoptosis

Details Use of xanthine derivatives for the modulation of apoptosis Use of xanthine derivatives for the modulation of apoptosis

1998-10-20

1999-11-09

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514264, 514907, A61K 3152

Patent

active

059815361

ABSTRACT:
Compounds of the formula I ##STR1## where one of the radicals R.sup.1 and R.sup.3 is a radical of the formula II --(CH.sub.2).sub.n --A--CH.sub.3 (II) in which A is a covalent bond,--C(O)-- or --C(R.sup.4)(OH)--, are suitable for the production of pharmaceuticals for the modulation of apoptosis. A combination preparation comprising a compound of the formula I and a compound of the formula IV and/or V ##STR2## is suitable for the production of pharmaceuticals for the modulation of apoptosis.

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R. Turner, "Use of Xanthine Derivs. esp. ---pentoxifylline---for inhibiting interleuken-8 elaboration and treating a symptom of an upper respiratory viral infection, esp. a rhinovirus infection", Derwent abstract No. 96-151131 for WO 96/05836, (1996).
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Mentz et al., Theophylline, a new inducer of apoptosis in B-CLL: role of cyclic nucleotides, British J. Haematol., vol. 90, No. 4, pp. 957-959 (1995).

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