Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-07-26
2005-07-26
Murphy, Joseph (Department: 1646)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S001000
Reexamination Certificate
active
06921773
ABSTRACT:
The present invention relates to the use of α1aAR-selective and/or α1a/α1d-selective antagonists in a method of preventing restenosis after myocardial infarction and re-perfusion. The invention further relates to a method of identifying agents suitable for us in such a method.
REFERENCES:
patent: 5767155 (1998-06-01), Chien et al.
patent: WO 98/15272 (1998-04-01), None
O'Malley MK, McDermott EW, Mehigan D, O'Higgins NJ. Role for prazosin in reducing the development of rabbit intimal hyperplasia after endothelial denudation. Br J Surg. 1989 Sep;76(9):936-8.
Chen and Gardner, “Retinoic Acid Uses Divergent Mechanisms to Activate or Suppress Mitogenesis in Rat Aortic Smooth Muscle Cells”, J. Clin. Invest. 102(4):653-662 (1998).
Braunhut and Moses, “Retinoids Modulate Endothelial Cell Production of Matrix-degrading Proteases and Tissue Inhibitors of Metalloproteinases (TIMP)”, The Journal of Biological Chemistry 269(18):13472-13479 (1994).
Davidson et al, “Ascorbate Differentially Regulates Elastin and Collagen Biosynthesis in Vascular Smooth Muscle Cells and Skin Fibroblasts by Pretranslational Mechanisms”, The Journal of Biological Chemistry 272(1):345-352 (1997).
Kagan, “Intra- and extracellular enzymes of collagen biosynthesis as biological and chemical targets in the control of fibrosis”, Acta Tropica 77:147-152 (2000).
Kivirikko and Myllyharju, “Prolyl 4-Hydroxylases and their Protein Disulfide Isomerase Subunit”, Matrix Biology 16:357-368 (1998).
Schwinn et al, “Cloning and Pharmacological Characterization of Human Alpha-1 Adrenergic Receptors: Sequence Corrections and Direct Comparison with Other Species Homologues”, The Journal of Pharmacology and Experimental Therapeutics 272(1):134-142 (1995).
Gregorini et al, “αAdrenergic Blockade Improves Recovery of Myocardial Perfusion and Function After Coronary Stenting in Patients With Acute Myocardial Infarction”, Circulation 99(4):482-490 (1999).
Razik et al, “Transcriptional Regulation of the Human α1a-Adrenergic Receptor Gene”, The Journal of Biological Chemistry 272(45):28237-28246 (1997).
Hoehe et al, “A two-allele PstlRFLP for the alpha-1C adrenergic receptor gene (ADRA1C)”, Human Molecular Genetics 1(5):349 (1992).
Hoehe et al, “Genetic mapping of adrenergic receptor genes in humans”, J Mol. Med. 73:299-306 (1995).
Andersson et al, “Prostatic α1-Andrenoceptors and Uroselectivity”, The Prostate 30:202-215 (1997).
Docherty, “Subtypes of functional α1-and α2-adrenoceptors”, European Journal of Pharmacology 361:1-15 (1998).
Richardson et al, “Pharmacology of Tamsulosin: Saturation-Binding Isotherms and Competition Analysis Using Cloned α1-Adrenergic Receptor Subtypes”, The Prostate 33:55-59 (1997).
Michel and Rump, “alpha-Adrenergic regulation of human and renal function”, Fundamental & Clinical Pharmacology 10(6):493-503 (1996)—Abstract.
Docherty and O'Rourke, “The α-Adrenoceptor-Mediated Actions of Chloroethylclonidine”, Gen. Pharmac. 28(2):197-201 (1997).
Graham et al, “α1-Adrenergic Receptor Subtypes”, Circulation Research 78:737-749 (1996).
Rudner et al, “Subtype Specific Regulation of Human Vascular α1-Adrenergic Receptors by Vessel Bed and Age”, Circulation 100:2336-2343 (1999).
Malloy et al, “α1-Adrenergic Receptor Subtypes in Human Detrusor”, The Journal of Urology 160:937-943 (1998).
Duke University
Murphy Joseph
Nixon & Vanderhye P.C.
LandOfFree
Use of α-1AR subtype-selective drugs in patients with... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of α-1AR subtype-selective drugs in patients with..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of α-1AR subtype-selective drugs in patients with... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3371622