Use of vindesine in treating acute lymphatic leukemia and _other

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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A61K 31475

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044799578

ABSTRACT:
This invention relates to a method of treating neoplasms which comprises administering to a mammal suffering from a vindesinesusceptible neoplasm selected from the group consisting of acute lymphatic leukemia, acute granulocytic leukemia, chronic myeloid leukemia, non-small cell lung cancer, Hodgkin's disease, non-Hodgkin's lymphoma, malignant melanoma carcinoma of the breast, esophageal carcinoma and testicular carcinoma an anti-neoplastically-effective amount of vindesine or a pharmaceutically-acceptable acid addition salt thereof.

REFERENCES:
Cancer, Sierocki, et al., Carcinoma Metastatic to the Anterior _Ocular Segment: Response to Chemotherapy, vol. 45, No. 10, 1980, _pp. 2521-2523.
Anticancer Research, Weber et al., The Evaluation of Neurotoxicity _in Cancer Patients Treated with Vinca Alkaloids with Special _Reference to Vindesine, 1:31-34(1981) pp. 31-34.
Anticancer research, Mathe, et al., Phase II Clinical Trials with _Vindesine in Patients with Hematologic Malignancies, 1:1-9, (1981), _pp. 1-9.
Cancer, Vats, et al., Vindesine and Prednisone for Remission _Induction in Children with Acute Lymphocytic Leukemia, vol. 47, No. 12, _Jun. 15, 1981, pp. 2789-2792.
Europ. J. Cancer, Houwen, et al., Vindesine Therapy in Melphalan-Resistant _Multiple Myeloma, vol. 17, 1981, pp. 227-232.
Proceedings of the International Vinca Alkaloid Symposium-Vindesine _(Symposium), Frankfurt, Germany, Nov. 1980, Table of _Contents, pp. 159-170; 214-220; 289-312; 422-429.
Cancer Chemotherapy and Pharmacology--Vindesine International Workshop--vol. 2, pp. 29-274 (1979).
Current Chemotherapy pp. 1328-1331; 1331-1334; 1334-1336 (1978).
Cancer Treatment Reports, 61, pp. 1727-1729 (1977); 62, pp. 805-809, _1427-1433(1978); 63, pp. 1343-1346; 2019-2021; 2063-2065; 2097-_2098(1979).
Vindesine Bibliography
Barnett et al., J. Med. Chem., 21, 88 (1978).

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