Use of tyloxapole as a nanoparticle stabilizer and dispersant

Details Use of tyloxapole as a nanoparticle stabilizer and dispersant Use of tyloxapole as a nanoparticle stabilizer and dispersant

1992-12-15

1995-07-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 91, 424490, 424497, 514951, 514975, A61K 914, A61K 951

Patent

active

054298245

ABSTRACT:
The present invention is directed to a composition comprised of nanoparticles having tyloxapol adsorbed on the surface thereof. In a preferred embodiment, said nanoparticle contains a diagnostic or therapeutic agent therein. In a further preferred embodiment, the nanoparticles contain a further surface modifier associated therewith. This invention further discloses a method of making nanoparticles having tyloxapol adsorbed on the surface, said method comprising contacting said nanoparticles with tyloxapol for a time and under conditions sufficient to provide a nanoparticle-tyloxapol composition. The present invention is also directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of particles of nanoparticles having tyloxapol adsorbed on the surface thereof, and generating a diagnostic image of said mammal.

REFERENCES:
patent: 4615879 (1986-10-01), Runge et al.
patent: 5234953 (1993-08-01), Crow et al.
patent: 5298262 (1994-03-01), Na et al.
patent: 5302401 (1994-04-01), Liversidge et al.
patent: 5318767 (1994-06-01), Liversidge et al.
patent: 5336507 (1994-08-01), Na et al.

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