Use of trifluoromethyl compounds

Details Use of trifluoromethyl compounds Use of trifluoromethyl compounds

1985-08-29

1987-01-27

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

046394591

ABSTRACT:
This disclosure describes a compound of Formula 1 ##STR1## (including its pharmaceutically acceptable salts and esters) which has potent antihistamine activity which is substantially free from sedative effects and which has little or no anticholinergic effects.

REFERENCES:
patent: 2567245 (1951-09-01), Sperber et al.
patent: 2712023 (1955-06-01), Adamson
patent: 3862173 (1975-01-01), Carr et al.
patent: 4355036 (1982-10-01), Villani
patent: 4501893 (1985-02-01), Findlay et al.
patent: 4562258 (1985-12-01), Findlay et al.
patent: 4584382 (1986-04-01), Findlay et al.
Burger, Medicinal Chemistry, 3rd ed., Part I, p. 76.
Chemical Abstracts, 71: 11415f (1968).
Buzas et al., J. Med. Chem. 1980, 23, 149-153.
Hucker et al., Drug Metabolism and Disposition, vol. 9, No. 5, pp. 428-433 (1981).
ASPET 1980, Abstract, Findlay et al., Pharmacokinetics of Triprolidine in Animals and Man as Measured by a New Radioimmunoassay, Wellcome Research Laboratories, Research Triangle Park, NC 27709.
PDR-1978-ACTIDIL (Triprolidine Hydrochloride) p. 707.
PDR-1978-ACTIFED-c (Expectorant-Tablets & Syrup) p. 708.

Affiliated with

Also associated with

Rating

Use of trifluoromethyl compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of trifluoromethyl compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of trifluoromethyl compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-858220