Use of trichostatin compounds for treating tumor cells

Details Use of trichostatin compounds for treating tumor cells Use of trichostatin compounds for treating tumor cells

1986-01-24

1987-09-01

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 172, 536 22, 536 187, A61K 3170

Patent

active

046909184

ABSTRACT:
A method for inducing the differentiation of tumor cells in human or animal, which comprises administering an effective amount of trichostatin A and/or trichostatin C to the human or animal.

REFERENCES:
patent: 4218478 (1980-08-01), Omura et al.
Yoshida et al., "Chem. Abst.", vol. 102, 1985, P. 199, 257 (s).
Morioka et al., "Chem. Abst.", vol. 104, 1985, p. 4632 (w).
Tsuji et al., "A New Antifungal Antibiotic, Trichostatin", J. of Antibiotics, vol. XXIX, No. 1, Jan. 1976, pp. 1-6.
Tsuji et al., "Trichostatin C, A Glucopyranosyl Hydroxamate", J. of Antibiotics, vol. XXXI, No. 10, Oct. 1978, pp. 939-944.
Fleming et al., "The Total Synthesis of (+)-Trichostatin A", Tetrahedron, vol. 39, No. 6, 1983, pp. 841-846.

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