Use of treosulfan for patient conditioning before bone...

Details Use of treosulfan for patient conditioning before bone... Use of treosulfan for patient conditioning before bone...

2007-04-03

2007-04-03

Wang, Shengjun (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Sulfur, selenium or tellurium compound

C514S079000, C514S110000

Reexamination Certificate

active

10129352

ABSTRACT:
The invention relates to the use of treosulfan as a conditioning agent before allogenic transplantation of bone marrow or haematopoietic stem cells, whereby treosulfan is administered, either as single effective agent, or in combination with other chemotherapetic agents or immunosuppressant agents.

REFERENCES:
Carter, Stephan K., M.D. et al.; Chemotherapy of Cancer, Second Edition, (1981); A Wiley & Sons, New York, New York; pp. 362-365.
Ploemacher, et al., Treosulfan as an Alternative Conditioning Agent in Bone Marrow Transplantation, Nov. 15, 1999, Blood, 94, 10 Suppl. 1 pt. 2, p. 324b.
Parkman, et al., Busulfan and Total Body Irradiation as Antihematopoietic Stem Cell Agents in the Preparation of Patients with Congenital Bone Marrow Disorders for Allogenic Bone Marrow Transplantation, 1984, Blood, 64(4), 852-7.
Parfitt, K. Ed. Martindale: The Complete Drug Reference, 32nd edition, 1999, pp. 509-511, 516-517 and 568.
Jabado, et al., Bone Marrow Transplantation from Genetically HLA-Nonidentical Donors in Children with Fatal Inherited Disorders Excluding Severe Combined Immunodeficiencies, 1996, Pediatrics, 98, 420-8.
Hirabayashi, et al., Busulfan, Cyclophosphamide and Total Body Irradiation as Conditioning for Allogenic Bone Marrow Transplantation for Acute and Chronic Myeloid Leukemia, 1998, Bone Marrow Transplant, 21, 1079-83.
Gulati et al., “Comparison of single-, double- or triple-exposure protocols for the rodent bone marrow/ peripheral blood micronucleus assay using 4-aminobiphenyl and treosulphan”Mutation Research234: 135-139 (1990).

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