Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-03-22
2005-03-22
Carlson, Karen Cochrane (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S350000
Reexamination Certificate
active
06869929
ABSTRACT:
The present invention provides a method of treating inflammation in a mammal comprising altering the activity of a transcription factor involved in the inflammatory response. The invention also relates to the use of transcription factors to screen compounds that are capable of reducing inflammation. The invention also relates to the use of transcription factors in methods of diagnosing the presence of an inflammatory disease in a tissue of a mammal and methods of monitoring the treatment of an inflammatory disease in a tissue of a mammal.
REFERENCES:
patent: 6024940 (2000-02-01), Ghio et al.
Rudders et al., “ESE-1 Is a Novel Transcriptional Mediator of Inflammation That Interacts with NF-κB to Regulate the Inducible Nitric-oxide Synthase Gene”, The Journal of Biological Chemistry, 276(5):3302-3309 (2001).
Goldring Mary
Libermann Towia
Oettgen Peter
Beth Israel Deaconess Medical Center
Carlson Karen Cochrane
Conlin David G.
Edwards & Angell LLP
Rosenfield Jennifer K.
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