Use of tocotrienols for elevating IKBKAP gene expression...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S458000, C549S398000, C549S406000

Reexamination Certificate

active

07872042

ABSTRACT:
The present invention provides methods for elevating IKBKAP gene expression and the level of functional IKAP protein in cells, which are beneficial to human individual, such as an individual suffering from Familial Dysautonomia, by providing one or more tocotrienols alone or in combination with one or more tocopherols to the cells. The present invention also provides methods for treating Familial Dysautonomia by providing tocotrienols alone or in combination with one or more tocopherols to a patient having Familial Dysautonomia. Related therapeutic kits are also provided.

REFERENCES:
patent: WO 96/19218 (1996-06-01), None
patent: WO 00/78296 (2000-12-01), None
patent: WO 2005/009135 (2005-02-01), None
Nesaretnam et al Abstract Lipids 1998 33 461.
Chatelain et. al., Biochimica et Biophysica Acta, 1993, Elsevier Science Ltd., vol. 1176, pp. 83-89.

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