Use of tiagabine for treatment of diabetic neuropathy and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

06872734

ABSTRACT:
(R)-N-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid and salts thereof are effective GABA uptake inhibitory compounds and exert pharmacological effects on pain associated with diabetic neuropathy and migraine.

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patent: 9937302 (1999-07-01), None
Attal, N., Douleur et Analgesis, 12/3:231-241 (Abstract) (1999).
Freitag et al., Headache Quarterly, 11/2:133-134 (abstract) (2000).
Giardina et al., “An Evaluation of the GABA Uptake Blocker Tiagabine in Animal Models of Neuropathic an dNociceptive Pain,” Drug Development Research 44:106-113 (1998).
Krogsgaard-Larsen, “Inhibitors of the GABA Uptake Systems”, Molecular & Cellular Biochemistry, vol. 31, 1980, p. 105-121.
Ross, E. L., Neurology, 55/5 Suppl. 1:S41-S46 (2000).
Yunger et al., “Novel Inhibitors of γ-Amniobutyric Acid (GABA) Uptake : Anticonvulsant Actions in Rats and Mice”, The Journal of Pharmacology and Experimental Therapeutics., Vol 228, No. 1, 1984, p. 109 et seq.

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