Use of thymulin-like peptides for making pain-relieving...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C530S328000

Reexamination Certificate

active

10492170

ABSTRACT:
The present invention relates to the utilization of peptide analogues of thymulin that are inactive relative to the immune system, not comprising zinc and having anti-pain activity, for manufacturing a medicine for the treatment of pain.

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Safieh-Garabedian et al., Neuroimmunomodulation 1999, vol. 6 pp. 39-44.
Evers et al., J. Neurol. 1999, vol. 246, pp. 802-809.
Dardenne et al., Contribution of zinc and other metals to the biological activity of the serum thymic factor, 1982, Proc. Natl. Acad. Sci. 79, 5370-5373.
Pleau et al., Antagonistic analogue of serum thymic factor interacting with the FTS cellular receptor, 1979, Immunology Letters 1, 179-182.
Bared Safieh-Garabedian, et al., “Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat,” British Journal of Pharmacology, vol. 136, pp. 947-955, 2002.
Bared Safieh-Garabedian, et al., “Cytokine-Mediated or Direct Effects of Thymulin on the Nervous System as Assessed by Pain-Related Behavior,” Neuroimmunomodulation, vol. 6, pp. 39-44, 1999.

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