Use of thrombin-derived peptides for the therapy of chronic...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S012200, C514S014800, C530S350000

Reexamination Certificate

active

07049294

ABSTRACT:
Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.

REFERENCES:
patent: 5352664 (1994-10-01), Carney et al.
patent: 5500412 (1996-03-01), Carney et al.
patent: WO 88/03151 (1988-05-01), None
patent: WO 96/40033 (1996-12-01), None
patent: WO 01/49309 (2001-07-01), None
HGS, Backgounder, Internet Publication, Sep. 2000.
Press Release: Chrysalis BioTechnology to begin clinical trials, (Sep. 24, 1998).
Press Release: Chrysalis Announces Completion of Pilot Chrysalin® Clinical Trial for Diabetic Ulcers, (Aug. 21, 2001).
Stiernberg, J., et al., “Acceleration of full-thickness wound healing in normal rats by the synthetic thrombin peptide, TP508,”Wound Repair and Regeneration, 8(3):204-215 (2000).
Norfleet, A.M., et al., “Thrombin peptide, TP508, stimulates angiogenic responses in animal models of dermal wound healing, in chick chorioallantoic membranes, and in cultured human aortic and microvascular endothelial cells,”General Pharmacology,35:249-254 (2002).
Norfleet, A.M., et al., “Thrombin peptide TP508 accelerates closure of dermal excisions in animal tissue with surgically induced ischemia,”Wound Repair and Regeneration,8(6):517-529 (2000).
Pernia, S.D., et al., “A Synthetic Peptide Representing the Thrombin Receptor-Binding Domain Enhances Wound ClosureIn Vivo,” SAAS Bulletin: Biochem.&Biotech.,3:8-12 (1990).
Carney, Darrell H., “Postclotting Cellular Effects of Thrombin Mediated by Interaction with High-Affinity Thrombin Receptors,” InThrombin Structure and Function, Berliner, L.J. (ed.) (New York: Plenum Press), pp. 351-396 (1992).
Stiernberg, J., et al., “The Role of Thrombin and Thrombin Receptor Activating Peptide (TRAP-508) in Initiation of Tissue Repair,”Thrombosis and Haemostasis,70(1)158-162 (1993).
Carney, D.H., et al., “Enhancement of Incisional Wound Healing and Neovascularization in Normal Rats by Thrombin and Synthetic Thrombin Receptor-activating Peptides,”J. Clin. Invest., 89:1469-1477 (1992).
Carney, D.H., et al., “Role of High-Affinity Thrombin Receptors in Postclotting Cellular Effects of Thrombin,”Seminars in Thrombosis and Hemostasis, 18(1):91-102 (1992).
Glenn, K.C., et al., “Synthetic Peptides Bind to High-Affinity Thrombin Receptors and Modulate Thrombin Mitogenesis,”Peptide Research, 1(2):65-73 (1988).
Sower, L.E., et al., “Thrombin Peptide, TP508, Induces Differential Gene Expression in Fibroblasts through a Nonproteolytic Activation Pathway,”Experimental Cell Research, 247:422-431 (1999).
Steed, D.L., et al., “Promotion and Acceleration of Diabetic Ulcer Healing by Arginine-Glycine-Aspartic Acid (RGD) Peptide Matrix,”Diabetes Care, 18(1):39-46 (1995).
Hollenberg, Morley D., et al., “Synergistic Actions of a Thrombin-Derived Synthetic Peptide and a Thrombin Receptor-Activating Peptide in Stimulating Fibroblast Mitogenesis,”J. Cell Physiol.169:491-496 (1996).
Remarks paper by Steven G. Davis, Esq., Hamilton, Brook, Smith & Reynolds, P.C., dated Nov. 28, 2005.

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