Use of thiazolidinediones to ameliorate the adverse consequences

Details Use of thiazolidinediones to ameliorate the adverse consequences Use of thiazolidinediones to ameliorate the adverse consequences

1999-01-14

1999-10-19

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514370, A61K 31425

Patent

active

059689609

ABSTRACT:
The present invention provides methods and compositions for (a) enhancing resistance to myocardial ischemia associated dysfunction, including contraction (systolic), relaxation (diastolic) and metabolic dysfunction, comprising the step of administering to a human determined to be susceptible to myocardial ischemia an effective amount of an insulin sensitizer; and (b) reducing hypertension comprising the step of administering to a hypertensive human determined to have normal insulin sensitivity, an effective amount of an insulin sensitizer. In a particular embodiment, the sensitizer comprises a thiazolidinedione compound, such as triglitazone.

REFERENCES:
patent: 4444779 (1984-04-01), Kawamatsu et al.
patent: 4572912 (1986-02-01), Yoshioka et al.
patent: 4703052 (1987-10-01), Eggler et al.
patent: 5814647 (1998-09-01), Urban et al.

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