Use of thiazole derivatives for preparing a medicine for...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S838000

Reexamination Certificate

active

10483823

ABSTRACT:
The invention concerns compounds of general formula (I), wherein: A represents one of the radicals in which R5represents independently a hydrogen atom, or alkyl; R6, R7and R8independently represent a hydrogen atom, alkyl, cycloalkyl, hydroxy or alkoxy; R11represents a hydrogen atom of alkyl; and R9, R10and R12independently represent a hydrogen atom, alkyl, hydroxy or alkoxy; B represents a hydrogen atom or alkyl; n represents an integer from 0 to 5; R1and R2independently represent a hydrogen atom, alkyl or cycloalkyl; R3and R4independently represent a hydrogen atom or an alkyl radical, or R3and R4together form with the nitrogen atom which bears them a heterocycle optionally substituted comprising in all 1 to 2 heteroatoms and 5 to 7 members. Said compounds can be used for preparing a medicine for protecting mitochondria, and in particular a medicine for preventing or treating cirrhosis.

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Danziger et al., Automated Site-directed Drug Design: A General Algorithm for Knowledge Acquisition about Hydrogen-Bonding Regions at Protein Surfaces, Mar. 22, 1989, The Royal Society, Proceedings of the Royal Society of London.Series B, Biological Sciences, vol. 236, No. 1283, p. 101-113.
Wyatt et al, “Structure-activity . . . Antagonist”, Bioorganic & Medicinal Chemistry Letters (2001), 11(10), 1301-1305, XP001066283.

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