Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-03-22
2011-03-22
Graser, Jennifer E (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C004S590000, C004S590000
Reexamination Certificate
active
07910317
ABSTRACT:
It is generally accepted that salivary components are important for dental health, but till now no clear correlation has been found between one or more of said components and the onset of dental caries. The present invention relates to an assay method comprising analysing the presence and/or the content of the salivary soluble CD14 protein from a saliva sample of the individual subjected to examination; the absence of said protein from the salivary sample, or its presence in a reduced amount compared to a predetermined threshold value in caries-free individuals, is considered as a marker of susceptibility to developing caries and/or as a diagnostic element for the existence of ongoing carious lesions.
REFERENCES:
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Bergandi et al (Eur.J.Oral Sci. 2007. 115:93-96).
Sakurai K et al., “Co-increase of nerve fibers and HLA-DR-and/or factor-XIIIa-expressing dendritic cells in dentinal caries-affected regions of the human dental pulp: An immunohistochemical study”, Journal of Dental Research; vol. 78, No. 10, Oct. 1999, pp. 1596-1608, XP009078056.
Ghafouri, Bijar et al., “Mapping of proteins in human saliva using two-dimensional gel electrophoresis and peptide mass fingerprinting.”, Proteomics, vol. 3, No. 6, Jun. 2003, pp. 1003-1015, XP009078068.
Uehara et al., Constitutive Expression of a Bacterial Pattern Recognition Receptor, CD14, in Human Salivary Glands and Secretion as a Soluble Form in Saliva, Clinical and Diagnostic Laboratory Immunology, vol. 10, No. 2, Mar. 2003, p. 286-292.
Bergandi Loredana
Ghigo Dario
Graser Jennifer E
Roylance Abrams Berdo & Goodman L.L.P.
Universita Degli Studi di Torino
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