Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1993-06-04
1994-08-16
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514903, 549218, A61K 31665, C07F 9141
Patent
active
053387309
ABSTRACT:
A process for preparing the (R) stereoisomer of 2,2-bis(hydroxmethyl)-tetrahydrofuran monobutyrate comprising subjecting the dibutyric ester of the 2,2-bis(hydroxymethyl)-tetrahydrofuran to enzymatic hydrolysis. The invention also relates to the novel (R) stereoisomer prepared by the instant process and to its more stable forms. In addition, the invention relates to the use of the (R) stereoisomer in preparing stereoisomers of pharmacologically active compounds and to certain specific stereoisomers produced thereby.
REFERENCES:
patent: 4601987 (1986-07-01), Klibanov et al.
patent: 4673672 (1987-06-01), Houlihan et al.
Chemistry Letters, pp. 1717-1720 (1988).
Biotechnology, vol. 7A, p. 113 (1987).
Tetrahedron Letters, vol. 31, No. 4, pp. 445-448 (1990).
Tetrahedron, vol. 42, No. 13, pp. 3351-3403 (1986).
Estermann Heinrich
Houlihan William J.
Kapa Prasad K.
Underwood Russell L.
Borovian Joseph J.
Honor Robert S.
Kassenoff Melvyn M.
Sandoz Ltd.
Tsang Cecilia
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