Use of the R-enantiomers of N-propargyl 1-aminoindan compounds f

Details Use of the R-enantiomers of N-propargyl 1-aminoindan compounds f Use of the R-enantiomers of N-propargyl 1-aminoindan compounds f

1994-06-07

1995-09-26

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564308, A61K 31135

Patent

active

054534461

ABSTRACT:
R(+)-N-p-opargyl-1-aminoindan, its preparation and use and pharmaceutical compositions containing it. The novel compound was found to be useful for the treatment of human patients for Parkinson's disease, memory disorders, dementia of the Alzheimer type (DAT), depression and the hyperactive syndrome.

REFERENCES:
patent: 3201470 (1965-08-01), Huebner
patent: 3253037 (1966-05-01), Huebner
patent: 3513244 (1970-05-01), Gittos et al.
patent: 4826875 (1989-05-01), Chiesi
Finberg and Youdim, Modification of blood pressure and nictitating membrane response to sympathetic amines by selective monoamine oxidase inhibitors, types A and B, in the cat British J. Pharmac. (Jun. 1985) 85(2):541-546.
Kabins and Gershon, Potential applications for monoamine oxidase B inhibitors Dementia (1990) 1:323-348.
The Merck Index (Tenth ed. 1983) pp. 149, 248-249.
The Parkinson Study Group, Effect of deprenyl on the progression of disability in early Parkinson's disease. New England J. Med. (1989) 321(20):1364-1371.
The Parkinson Study Group, Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease, New England J. Med. (Jan. 21, 1993) 328(3):176-183.
Riederer and Youdim, Monoamine oxidase activity and monoamine metabolism in brains of Parkinsonian patients treated with 1-deprenyl, J. Neurochem. (1986) 46(5):1359-1365.
Tekes, et al., Effect of MAO inhibitors on the uptake and metabolism of dopamine in rat and human brain, Pol. J. Pharmacol. Pharm. (1988) 40:653-658.
Youdim et al. in Handbook of Experimental Pharmacology vol. 90/I (1988) Chapter 3, Trendelenburg and Weiner, eds.

Affiliated with

Also associated with

Rating

Use of the R-enantiomers of N-propargyl 1-aminoindan compounds f does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of the R-enantiomers of N-propargyl 1-aminoindan compounds f, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of the R-enantiomers of N-propargyl 1-aminoindan compounds f will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1552107