Use of the polypeptide compound

Details Use of the polypeptide compound Use of the polypeptide compound

1994-09-26

1997-03-04

Jordan, Charles T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, A61K 3800

Patent

active

H00016381

ABSTRACT:
A pharmaceutical composition comprising an amount of a polypeptide of the formula: ##STR1## wherein R.sup.1 is hydrogen or an acyl group, R.sup.2 is hydroxy or an acyloxy group, R.sup.3 is hydrogen, hydroxy or hydroxysulfonyloxy, R.sup.4 is hydrogen or carbamoyl, and R.sup.5 and R.sup.6 are each hydrogen or hydroxy, with the proviso that (i) R.sup.2 is acyloxy when R.sup.3 is hydrogen, and (ii) R.sup.5 is hydrogen when R.sup.6 is hydrogen, or a pharmaceutically acceptable salt thereof, is useful in the prevention or treatment of Pneumocystis carinii infection.

REFERENCES:
patent: 4287120 (1981-09-01), Abbott et al.
patent: 4320052 (1982-03-01), Abbott et al.
patent: 4320053 (1982-03-01), Abbott et al.
patent: 4322338 (1982-03-01), Abbott et al.
patent: 5376634 (1994-12-01), Iwamoto et al.
Schmatz et al, Proc. Natl. Acad. Sci., USA, vol. 87, pp. 5950-5954, 1990.

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