Use of the enantiomers of ifosfamide in antitumor therapy for re

Details Use of the enantiomers of ifosfamide in antitumor therapy for re Use of the enantiomers of ifosfamide in antitumor therapy for re

1998-03-23

2000-03-14

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

A61K 3166

Patent

active

060373377

ABSTRACT:
(R)-Ifosfamide is administered as a cytotoxic drug, in order to minimize side effects. (S)-Ifosfamide may be administered subsequently.

REFERENCES:
Kleinrok, Zdzislaw et al. (1986) "Pharmacological evaluation of ifosfamide and its enantiomers in laboratory animals," Arch. Immunol. Ther. Exp., vol. 34, pp. 293-304.
Kusniercyzk, H. et al. (1986) "Antitumor activity of optical isomers of cyclophosphamide, ifosfamide and trofosfamide as compared to clinically used racemates," J. Immunopharmacol., vol. 8, pp. 455-480.
Wainer, I.W. et al. (1994) "Efficacy and toxicity of ifosfamide stereoisomers in an in vivo rat mammary carcinoma model," Cancer Res., vol. 54, pp. 4393-4397.
Masurel, Dominique et al. (1990) "Efficacy, toxicity, pharmacokinetics, and in vitro metabolism of the enantiomers of ifosfamide in mice," Cancer Res., vol. 50, pp. 252-255.
B. Testa et al. (1990) "Racemates Versus Enantiomers in Drug Development: Dogmatism or Pragmatism?" Chirality, vol. 2, pp. 129-133.
Blaschke, G. et al. (1986) "Preparative isolation and pharmacological-toxicological studies of the enantiomers of ifosfamide," Arzneim.-Forsch., vol. 36, pp. 1493-1495.

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