Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-04-10
1990-06-19
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3141
Patent
active
049354353
ABSTRACT:
The invention provides a method for the treatment of a human or animal patient suffering from, or subject to, an arthritic or related autoimmune disorder, a connective tissue disorder or transplant rejection, using a compound which is a tetrazole derivative of the formula: ##STR1## wherein R.sup.1 represents halogen, alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulphamoyl, dialkylsulphamoyl, dialkylamino, dialkylcarbamoyl, alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl, alkanoylamino, cycloalkylcarbonyl, hydroxy, formyl, nitro, trifluoromethyl, trifluoroacetyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl, benzyloxy, aralkanoyl, aroyl, or a group of the formula --CR.sup.2 .dbd.NOR.sup.3 wherein R.sup.2 represents hydrogen, alkyl, aryl, aralkyl, trifluoromethyl or cycloalkyl, and R.sup.3 represents hydrogen, alkyl, optionally substituted by phenyl, or represents optionally substituted aryl and m represents zero, 1, 2 or 3, or a pharmaceutically acceptable salt thereof.
Friedman Stanley J.
May & Baker Limited
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