Use of tetrandrine and its derivatives to treat malaria

Details Use of tetrandrine and its derivatives to treat malaria Use of tetrandrine and its derivatives to treat malaria

1989-09-28

1991-06-18

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514281, 514895, A61K 3144

Patent

active

050250205

ABSTRACT:
The specification discloses the treatment of malaria through the use of tetrandrine and its derivatives.

REFERENCES:
Kawashima et al., Gen. Pharmac., vol. 21 #3, pp. 343-347.
Fang et al., Jour. of Hypertension, 1986, 4(Suppl 6)s-150-152.
Qian et al., Hypotensive Activity of Tetrandrine in Rats, Pharmacology 26: pp. 187-197, 1983.
Gralla et al., Toxicology Studies with d-Tetrandrine, Cancer Chemotherapy Reports Part 3, vol. 5 #1, 1974, pp. 79-85.
Dept. of Pharmacology et al., A Clinical Study of Antihypertensive Effect of Tetrandrine, Chinese Medical Jour. 92(3), pp. 193-198, 1979.
Martin et al., Science, Feb. 20, 1987, pp. 899-901.
Potentiation of Antitumor Activity of Vincristine by the Biscoclaurine Alkaloid Cepharanthine, Kato et al., JNCI, vol. 79(3), Sep. 1987, pp. 527-532.
Biochemical Effects of d-Tetrandrine and Thalacarpine, Creasey, 1976, Biochemical Pharmacology, vol. 25, pp. 1887-1891.
Cepharanthine and Multidrug Resistance, Shiraishi et al., 1987, Cancer Research 47, 2413-2416.
Reversal of Cloroquine Resistance In Falciparum Malaria Independent of Calcium Channels, Ye et al., 1988, Biochemical & Biophysical Res. Com., 155(1), pp. 476-481.
Mitscher et al., CA75: 59822w, 1971.
Miana et al., CA 72:55716e, 1970.

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