Use of tetramethylpyrazine in the treatment of brain tumor

Details Use of tetramethylpyrazine in the treatment of brain tumor Use of tetramethylpyrazine in the treatment of brain tumor

2006-08-15

2006-08-15

Low, Christopher S. F. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S247000

Reexamination Certificate

active

07091205

ABSTRACT:
The present invention relates to the use of tetramethylpyrazine (TMP) in the treatment of brain tumor.

REFERENCES:
HCAPLUS DN: 138:276225, Zhao et al., CN 1362064 A Aug. 7, 2002, abstract only.
HCAPLUS DN:119:85568, Liu et al., Zhongguo Yaolixue Yu Dulixue Zazhi, 7(2), 149-52 (1993), abstract only.
Takano, T., et al., “Glutamate release promotes growth of malignant gliomas,”Nature Medicine,7(9):1010-1015 (2001).
Ishiuchi, I., et al., “Blockage of Ca2+-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells,”Nature Medicine,8(9):971-978 (2002).
Tsai, T., et. al., “Pharmacokinetics of tetramethylpyrazine in rat blood and brain using microdialysis,”International Journal of Pharmaceutics,216:61-66 (2001).
Shih, Y., et al., “Protective effects of tetramethylopyrazine on kainite-induced excitotoxicity in hippocampal culture,”NeuroReport,13(4):515-519 (2002).
Pang, P., et al., “Tetramethylpyrazine, a Calcium Antagonist,”Planta Medica,62:431-435 (1996).
Ye, Z-C, et al., “Glioma Cells Release Excitotoxic Concentrations of Glutamate,”Cancer Research,59:4383-4391 (Sep. 1, 1999).

Affiliated with

Also associated with

Rating

Use of tetramethylpyrazine in the treatment of brain tumor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of tetramethylpyrazine in the treatment of brain tumor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of tetramethylpyrazine in the treatment of brain tumor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3670400