Use of tetrahydrothienopyridine derivatives as angiogenesis inhi

Details Use of tetrahydrothienopyridine derivatives as angiogenesis inhi Use of tetrahydrothienopyridine derivatives as angiogenesis inhi

1992-02-11

1993-07-06

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3147

Patent

active

052254208

ABSTRACT:
The invention relates to the use of compounds of the formula ##STR1## in which p is 2 and q is 1 or p is q and q is 2; Ar represents an optionally substituted phenyl, and Z represents NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which may be identical or different, represent H or optionally substituted alkyl or, with the nitrogen atom, form a saturated heterocycle, or Z represents OR in which R is H or optionally substituted alkyl, or their addition salts, in the form of pure enantiomer or of mixtures thereof, for administration in a human patient for preventing or treating pathologies involving or dependent upon a neovascularization.

REFERENCES:
R. A. Fraser et al., "Role of Mast Cells in Experimental Tumour Antiogenesis," Ciba Foundation Symposium 100, pp. 120-131, 1983.
R. L. Barnhill et al., et al., "Biochemical Modulation of Angiogenesis in the Chorioallantoic Membrane of the Chick Embryo," J. Invest. Dermatol., vol. 81, No. 6, pp. 485-488, 1983.
R. Feliste et al., "Broad Spectrum Anti-Platelet Activity of Ticlopidine and PCR 4099 Involves the Suppression of the Effects of Released ADP," Thromb. Res., vol. 48, No. 4, pp. 403-415, 1987.
J. P. Maffrand et al., "Nouvelles Therapeutiques Antiagregantes," Sang Thromb. Vaiss., vol. 2, No. 4, pp. 175-177, 1990.

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