Use of tetrahydrocortisol in glaucoma therapy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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Details

514178, 514182, 514913, 514914, A61K 3156

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active

048639125

ABSTRACT:
Pharmaceutical compositions comprising tetrahydrocortisol and method of using same in the control of intraocular pressure are disclosed.

REFERENCES:
patent: 2783226 (1957-02-01), Gould et al.
Chemical Abstracts, vol. 88 (1978), #99603a; Halatek et al.
Chemical Abstracts, vol. 90 (1979); 198072z, Gierkowa et al.
Meyer et al., "Influence of Norethynodrel with Mestranol on Intraocular Pressure in Glaucoma", Arch Ophthal, vol. 75, Jun. 1966.
Treister et al., "Intraocular Pressure and Outflow Facility", Arch. Ophthal, vol. 83, Mar. 1970.
Lamble et al., "Some Effects of Progestogens, Oestrogens and Androgens on the Ocular Tension of Rabbits and Owl Monkeys", Exp. Eye Res., 26, 599-610, (1978).
Southren, et al., "5-beta-dihydrocortisol: Possible Mediator of the Ocular Hypertension in Glaucoma", Investigative Ophthalmology & Visual Science, Mar. 1985, vol. 26, pp. 393-395.
Crum, et al., "A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment", Science, Dec. 20, 1985, vol. 230, pp. 1375-1378.

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