Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 3,10-dihydroxy-2-naphthacene carboxamide or derivative doai
Patent
1992-05-04
1994-07-05
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
3,10-dihydroxy-2-naphthacene carboxamide or derivative doai
514899, A61K 3165
Patent
active
RE0346560
ABSTRACT:
Tetracyclines, antibacterial and non-antibacterial tetracyclines, have been found to be useful in the treatment of osteoporosis in humans by administering to the human suffering from osteoporosis an effective amount of a tetracycline to enhance bone protein synthesis. Tetracyclines which have been found to be effective in the treatment of osteoporosis in humans include minocycline, doxycycline and dedimethylaminotetracyline.
REFERENCES:
patent: 2895880 (1959-07-01), Rosenthal
patent: 3304227 (1967-02-01), Loveless
patent: 3636202 (1972-01-01), Klein
patent: 3914299 (1975-10-01), Muxfeldt
patent: 4248892 (1981-02-01), Kanamaru et al.
patent: 4276284 (1981-06-01), Brown
patent: 4371465 (1983-02-01), McGregor
patent: 4454110 (1984-06-01), Caslavsk et al.
patent: 4457936 (1984-07-01), Draeger et al.
patent: 4666897 (1987-05-01), Golub et al.
patent: 4704383 (1987-11-01), McNamara et al.
patent: 4925833 (1990-05-01), Golub et al.
patent: 4935411 (1990-06-01), McNamara et al.
patent: 4935412 (1990-06-01), McNamara et al.
Golub, et al., Chemical Abstracts, 100:96203a, (1984).
Engesaeter, et al., Chemical Abstracts, 93:142977t, (1980).
Smirnov, I. V., Chemical Abstracts, 76:30596, (1969).
Valcavi, et al., Chemical Abstracts, 95:6899h, (1981).
Brandt, et al., Chemical Abstracts, 92:163746m, (1979).
Glantz, et al., Chemical Abstracts, 91:20178w, (1979).
Muxfeldt, Chemical Abstracts, 76:140344j, (1972).
Bitha, et al., Chemical Abstracts, 72:43253P, (1970).
Myl'nikova, Chemical Abstracts, 86:66138h, (1976).
Plakunov, Chemical Abstracts, 80:104410b, (1973).
Dreisbach, et al., "Induction of Collagenase Production in Vibrio B--30", J. Bacteriology, vol. 135, No. 2, pp. 521-527, (1978).
Goodman and Gilman, The Pharmacological Basis of Therapeutics, 6th edition, p. 961-2, (1980).
Perry, et al., "Systemic Tetracycline in the Treatment of Non-Infected Corneal Ulcers and Persistent Epithelial Defects", J. Period Res. 83:20, 185-195 (Abstract and Artide) (1984).
Gomes, et al., "Tetracyclines Inhibit Parathyroid Hormone-Induced Bone Resorption in Organ Culture", School of Dental Medicine Study, SUNY, (Mar. 19, 1984).
Goodson, et al., "Monolithic Tetracycline-containing Fibers for Controlled Delivery to Periodontal Pockets", J. Periodontol. 54 575-579 (Jan. 1983).
"Anti-Plaque Agents", Pharmacy Times, 97 (Jul. 1985).
"Periodontal Disease Research, Guide to Dental Health", Journal of the American Dental Association, 70-74 (1985).
"British Bio-Technology Group's Collagenase Inhibitor Adjunctive", F-D-C Reports, Inc., 13 (1983).
ALZA/P&G Periodontal Disease Partnership:Actisite, F-D-C Reports, Inc., 8-9 (1990).
"Zyderm Collagen Treatments", Collagen Corporation, Advertisement, (Dec. 1981).
O'Donovan, J. P., "A Chick Screen to Evaluate Chemical Compounds from Janssen Pharmaceutical for Growth Promotion", Chick Growth Promotion Screen Report (1987).
Katz, S. E., "Is Today's Meat Fit to Eat?", Chemical and Engineering News, 80-81 (Mar. 11, 1985).
Golub, et al., "Minocycline Therapy Reduces Gingival Collagenolytic Enzyme Activity During Diabetes: A Proposed New Mechanism of Action, J. Of Periodontal Research", 18: 516-526, Abstract, (1983).
Golub, et al., "Minocycline Reduces Gingival Collagenolytic Activity During Diabetes", Journal of Periodontal Research, 18: 516-526 (1983).
Golub, et al., "Minocycline Therapy Inhibits the Abnormal Gingival Collagenolytic Activity During Experimental Diabetes", Journal of Dental Research, 62:290, Abstract 1085, (1983).
Williams et al., "Tetracycline Treatment of Periodontal Disease in the Beagle Dog:", Journal of Periodontal Research, 16:555-674, (1981).
Brown et al., "Rheumatoid Artritis in the Gorilla:A Study of Mycoplasma-Host Interaction in Pathogenesis and Treatment", Comarative Pathology of Zoo Animals, 259-266, (1980).
Berman, M. B., "Collagenase and Corneal Ulceration", 8:141-174, (1980).
Addy, et al., "The Development and in Vitro Evaluation of Acrylic Strips and Dialysis Tubing for Local Drug Delivery", J. Periodonal, 693-699, (Nov. 1982).
Addy, et al., "Comparison of the Immediate Effects on the Subgingival Microflora of Acrylic Strips Containing 40% Chlorhexdine, Metronidazole or Tetracycline", Journal of Clinical Periodontology, 11:379-386, (1984).
Sheridan, P., "Tetracyclines Block Collagenase Activity", JAMA, 252, 1989-1990 (Oct. 19, 1984).
Golub Lorne M.
McNamara Thomas F.
Ramamurthy Nungavaram S.
Cintins Marianne M.
Criares T. J.
The Research Foundation of State University of New York
LandOfFree
Use of tetracycline to enhance bone protein synthesis and/or tre does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of tetracycline to enhance bone protein synthesis and/or tre, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of tetracycline to enhance bone protein synthesis and/or tre will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-788465