Use of tenidap to inhibit activation of collagenase and to inhib

Details Use of tenidap to inhibit activation of collagenase and to inhib Use of tenidap to inhibit activation of collagenase and to inhib

1990-03-19

1991-04-16

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514418, 514912, 514814, 514415, 514419, A01N 4338

Patent

active

050082833

ABSTRACT:
This invention relates to the use of tenidap, 5-chloro-2,3-dihydro-2-oxo-3-(2-thienylcarbonyl)-indole-1-carboxamide, and the pharmaceutically-acceptable base salts thereof to inhibit activation of collagenase in a mammal and to inhibit the activity of myeloperoxidase in a mammal. This invention also relates to the use of tenidap and its salts for treating collagenase mediated disorders and diseases such as bone resorption disorders, corneal ulceration, periodontal disease, inflammatory disease and wounds of the skin and burns in mammals. The methods of this invention comprise administering an effective amount of tenidap or salts thereof to a mammal.

REFERENCES:
patent: 4556672 (1985-12-01), Kadin
patent: 4725616 (1988-02-01), Kadin
patent: 4853409 (1989-08-01), Showell
patent: 4861794 (1989-08-01), Otterness
patent: 4920127 (1990-04-01), King et al.
CA: 110(21) 185555r.
CA: 110(25) 229951y.
Hasty, K. A. et al., "Secreted Forms of Human Neutrophil Collagenase", J. Biol. Chem. 261: 5645-5650 (1986).
Hasty, K. A., et al., "The Collagen Substrate Specificity of Human Neutrophil Collagense", J. Biol. Chem. 262: 10048-10052 (1987).
Harris, E. D. et al., "Collagenases (First of Three Parts)", NEJM 291: 557-563 (1974).
Harris, E. D. et al., "Collagenases (Second of Three Parts)", NEJM 291: 605-609 (1974).
Harris, E. D. et al., "Collagenases (Third of Three Parts)", NEJM 291: 652-661 (1974).
Goldstein, I. M., "Agents that Interfere with Arachidonic Acid Metabolism", Inflammation: Basic Principles and Clinical Correlates, Gallin, J. I., Goldstein, I. M., and Snyderman, R., Eds. (1988), pp. 935-946, Raven Press, New York.
Weiss, S. J. et al., "Oxidative Autoactivation of Latent Collagenase by Human Neutrophils", Science 227: 747-749 (1985).
Mallya, S. K. et al., "Mechanism of Inhibition of Human Neutrophil Collagenase by Gold (I) Chrysotherapeutic Compounds", J. Biol. Chem. 264: 1594-1601 (1989).
Mallya, S. K. et al., "Inhibition of Human Neutrophil Collagenase by Gold(I) Salts Used in Chrysotherapy", Biochem. Biophys. Res. Comm. 144: 101-108 (1987).
Cuperus, R. A. et al., "Antiarthritis Drugs Containing Thiol Groups Scavenge Hypochlorite and Inhibit its Formation by Myeloperoxidase from Human Leukocytes", Arthritis Rheum. 28: 1228-1233 (1985).
Genetic Engineering News, p. 11, Nov./Dec. 1989.
Havemann, K., et al., "Physiology and Pathophysiology of Neutral Proteinases of Human Granulocytes", Adv. Exp. Med. Biol. 167: 1-20 (1984).
Showell, H. J., et al., J. Reticuloendothelial Society 30: 167-181 (1981).
Showell, H. J. et al., Life Sciences 27: 421-426 (1980).
Walenga, R. W. et al., Life Sciences 27: 1047-1053 (1980).
Serhan, C. N. et al., Biochem. Biophys. Res. Comm. 107: 1006-1012 (1982).
Smolen, J. E., et al., "Effects of Indomethacin, 5,8,11,14-Eicosatetraynoic Acid, and p-Bromophenacyl Bromide on Lysosomal Enzyme Release and Superoxide Anion Generation by Human Polymorphonuclear Leukocytes", Biochem. Pharmacol. 29: 533-538 (1980).
Turner, R. A. et al., "Effects of Benoxaprofen on Human Neutrophil Function", J. Rheumatology 11: 265-271 (1984).
Mikulikova, D. et al., "The Effect of Indomethacin and Its Ester on Lysosomal Enzyme Release from Polymorphonuclear Leukocytes and Intracellular Levels of cAMP and cGMP After Phagocytosis of Urate Crystals", Biochem. Pharmacol. 31: 460-463(1982).
Edelson, H. S. et al., "Dissociation by Piroxicam of Degranulation and Superoxide Anion Generation from Decrements in Chlortetracycline Fluorescence of Activated Human Neutrophils", Biochem. Biophys. Resl. Commun. 104: 274-253 (1982).
Maderazo, E. G. et al., "Inhibition of Human Polymorphonuclear Leukocyte Cell Responses by Ibuprofen", J. Pharmaceutical Sciences 73: 1403-1406 (1984).
Simchowitz, L. et al., "Chemotactic Factor-Induced Generation of Superoxide Radicals by Human Neutrophils", Arthritis and Rheumatism, 22: 755-763 (1979).
Abramson, S. et al., "Modes of Action of Aspirin-Like Drugs", P.N.A.S. 82: 7227-7231 (1985).
Minta, J. O. et al., "Some Nonsteroidal Antiinflammatory Drugs Inhibit the Generation of Superoxide Anions by Activated Polymorphs by Blocking Ligand-Receptor Interactions", J. Rheumatol. 12: 751-757 (1985).

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